{"id":15092,"date":"2023-06-23T17:30:49","date_gmt":"2023-06-23T07:30:49","guid":{"rendered":"https:\/\/metronorth.health.qld.gov.au\/extranet\/?p=15092"},"modified":"2023-06-26T12:02:26","modified_gmt":"2023-06-26T02:02:26","slug":"edr-20230623","status":"publish","type":"post","link":"https:\/\/metronorth.health.qld.gov.au\/extranet\/executive-messages\/edr-20230623","title":{"rendered":"Message from the Chief Executive and Executive Director Research"},"content":{"rendered":"

\"Executive

Professor Dan Chambers, Executive Director Research<\/p><\/div>\n

\"Jackie

Adj Assoc Prof Jackie Hanson, Chief Executive<\/p><\/div><\/p>\n

The inaugural Clinician Researcher Training Pathway (CRTP)<\/a> brings together The University of Queensland and Metro North Health to strengthen Australian clinical research through the identification, training, and support of our future medical, nursing, midwifery, and allied health research leaders.<\/h4>\n

It is designed to train and support future research experts through a structured and mentored pathway that includes time to prepare for and complete a PhD as well as protected time for post-doctoral research.<\/p>\n

We are extremely pleased to announce the recipients of the inaugural Clinician Research Training Pathway and would like to congratulate them on their success.<\/p>\n

Dr Eddie Shen<\/h3>\n

Title:<\/strong> Immunological profiling of sepsis-induced myocardial dysfunction (SIMD) and the role of bromodomain and extra-terminal domain (BET) containing protein inhibitors in a translational (cardiac organoid) model.
\nPrincipal Supervisor:<\/strong> Associate Professor Jayesh Dhanani
\nAssociate Advisors:<\/strong> Professor Michael Reade, Professor James Hudson and Dr Simon Foster<\/p>\n<\/div>

\"Dr<\/p>\n

Dr Shen\u2019s project aims to develop an innovative preclinical model for investigating a potential new class of therapeutics for sepsis-mediated cardiac dysfunction. Septic shock is characterised by a dysregulated host response to infection with a mortality rate up to 40%; with sepsis-induced myocardial dysfunction (SIMD) a recognised complication in ~50% of patients presenting with sepsis. Whilst there is yet no targeted therapies to address SIMD, preclinical evidence suggests a role of bromodomain and extra-terminal domain (BET) inhibitors and this study aims to assess the effects of serum isolated from septic patients via a cardiac organoid model, and the role of BETi in modulating carious cytokine profiles. The study also aims to obtain a better understanding of the pharmacokinetics of BETi in an LPS sheep model.<\/p>\n

Ms Jane Wickins<\/h3>\n

Title:<\/strong> Preventing catheter associated infections in adults in the acute inpatient setting.
\nPrincipal Supervisor:<\/strong> Professor Claire Rickard
\nAssociate Advisor:<\/strong> Professor Nicole Marsh<\/p>\n<\/div>

\"Ms<\/p>\n

Ms Wickins\u2019s research plan aims to help prevent urinary catheter associated infections in adults in the acute inpatient setting (CAUTI) in adults in the acute hospital setting. CAUTI prevention is based on standardisation of urinary catheterisation nursing practices to promote adherence to evidence-based guidelines. The project will:<\/p>\n