{"id":9173,"date":"2022-04-07T13:40:52","date_gmt":"2022-04-07T03:40:52","guid":{"rendered":"https:\/\/metronorth.health.qld.gov.au\/staff-news\/?p=5748"},"modified":"2022-10-28T08:51:54","modified_gmt":"2022-10-27T22:51:54","slug":"heart-beating-strong","status":"publish","type":"post","link":"https:\/\/metronorth.health.qld.gov.au\/extranet\/newsletters\/tpch-newsletter\/heart-beating-strong","title":{"rendered":"Heart Beating Strong thanks to pioneering research at TPCH"},"content":{"rendered":"
\"Inspecting

Prof John Fraser, Director, TPCH\u2019s Critical Care Research Group, and Prof David McGiffin inspect the HEVP rig<\/p><\/div>\n

TPCH\u2019s Critical Care Research Group has been thanked by the American doctors behind the historic Pig-Human heart xenotransplant.<\/strong><\/p>\n

The surgery performed at the University of Maryland School of Medicine in January drew on the Critical Care Research Group\u2019s world leading understanding of the use of hypothermic ex vivo perfusion (HEVP) which keeps a heart \u2018alive\u2019 and metabolically healthy between donor and recipient. For six years CCRG has been undertaking extensive preclinical trials into the use of HEVP, leading to the same technology being used in the world first surgery in Maryland.<\/p>\n

\"CCRG

The genetically modified donor pig heart is examined before transplantation in Maryland, USA.<\/p><\/div>\n

During the years of lab preparations before the cardiac pig surgery, and after many unsuccessful heart transplants between species, University of Maryland surgeon Dr Bartley Griffith liaised with researchers at the Critical Care Research Group and implemented HEVP into his trials and quickly saw results. Inspired, his team then progressed with the successful pig heart to human transplant.<\/p>\n

\u201cFor some time, I have been following CCRG\u2019s impressive research and the subsequent clinical trials with great interest. Their preclinical results encouraged our use of the same system here and gave us confidence to move ahead with a transplant into a human,\u201d said Dr Griffith.
\nCCRG Founder and Director Professor John Fraser, who devised the heart transplant research six years ago, said the technology had already been used in 13 human to human cases in Australia, transporting hearts that may otherwise not have been viable for transplantation.<\/p>\n

\u201cHEVP allows a donated heart to be rejuvenated before transplantation, essentially kept alive with a medical \u2018Gatorade\u2019 solution rich in oxygen and nutrients,\u201d Professor Fraser said.<\/p>\n

\u201cThe world is taking notice of Queensland\u2019s innovative spirit and our many passionate and dedicated researchers. It\u2019s something we should all take pride in, that the studies we have spent almost 100,000 hours doing to help transplant recipients in Australia have now been a key component to the world first pig transplant in America.\u201d<\/p>\n

\u201cHowever, there\u2019s still so much to learn \u2013 heart disease is the biggest killer and it just gets bigger and bigger. There are many more potential heart transplant recipients than donors.\u201d<\/p>\n

The University of Queensland\u2019s Dr Louise See Hoe, who led the preclinical research at CCRG, said, \u201cOrgan shortage is the greatest challenge facing the transplant field today. Consequently, only a small number of patients with end-stage heart disease are given the opportunity of a transplant.\u201d<\/p>\n

\u201cOur research recently secured a new world record with a heart kept alive via HEVP for over 7 hours before transplantation. This work will ensure Australians with heart disease will have a greater chance of survival and that we can increase the number of hearts available for transplant each year.\u201d<\/p>\n

Australian-led research into the use of HEVP and the first successful xenotransplantation heralds a new era for organ transplantation, a practice that has remained relatively unchanged in more than five decades.<\/p>\n<\/div>

<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

TPCH\u2019s Critical Care Research Group has been thanked by the American doctors behind the historic Pig-Human heart xenotransplant.<\/p>\n","protected":false},"author":53,"featured_media":10629,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_searchwp_excluded":"","footnotes":""},"categories":[177],"tags":[],"class_list":["post-9173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tpch-newsletter"],"acf":[],"yoast_head":"\nHeart Beating Strong thanks to pioneering research at TPCH - Staff Extranet<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Heart Beating Strong thanks to pioneering research at TPCH - Staff Extranet\" \/>\n<meta property=\"og:description\" content=\"TPCH\u2019s Critical Care Research Group has been thanked by the American doctors behind the historic Pig-Human heart xenotransplant.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/metronorth.health.qld.gov.au\/extranet\/newsletters\/tpch-newsletter\/heart-beating-strong\" \/>\n<meta property=\"og:site_name\" content=\"Staff Extranet\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-07T03:40:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-27T22:51:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/metronorth.health.qld.gov.au\/staff-news\/wp-content\/uploads\/sites\/25\/2022\/04\/inspecting-hevp-device.jpg\" \/>\n<meta name=\"author\" content=\"nealeian\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/metronorth.health.qld.gov.au\/extranet\/newsletters\/tpch-newsletter\/heart-beating-strong\",\"url\":\"https:\/\/metronorth.health.qld.gov.au\/extranet\/newsletters\/tpch-newsletter\/heart-beating-strong\",\"name\":\"Heart Beating Strong thanks to pioneering research at TPCH - 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