Programs2021-03-01T10:32:23+10:00

Clinical Programs

The Herston Biofabrication Institute is supporting research within Metro North Hospital and Health Service through a range of biofabrication-focussed clinical programs.

2019 Programs

Our Orthopaedics program is led by orthopaedic surgeon A/Prof Kevin Tetsworth. It is focussed on the following collaborative research projects:

  • Multi-faceted approach to modelling continuously curved lattices to enhance bone in-growth (biomimetic designs).
  • Prospective assessment of the relationship between osteochondral injuries of the talar dome associated with pilon fractures.
  • Developing a new algorithm for proteoglycan loss and collagen degeneration – a finite element study.
  • Hybrid implant development: 3D printed implant to repair osteochondral defects.
  • Internal deformations in human knee and hip joint under axial compression – 9.4T MRI study.

Our Burns, Skin & Wounds program is led by burns and general surgeon Dr Jason Brown. It is focussed on the following collaborative research projects:

  • 3D patient assessment of burn depth and size to guide surgical planning and treatment using advanced 3D imaging technologies.
  • Post-operative burn scar management using 3D scanning, 3D modelling and 3D printing for custom pressure devices and prosthetics.
  • Virtual reality for procedural and peri-procedural pain and anxiety management.
  • Queensland Skin Culture Centre (QSCC) Biobank – RBWH HREC approved.
  • Skin regeneration using 3D bioprinting as an alternative to use of donor skin for burns patients.

2021 Sub-Program: Skin & Wounds (2021-2025)

  • Chronic wounds and effective solutions to restore skin function.
  • Skin organoids.
  • UQ collaborators: Prof Kiarash Khostrotehrani (Diamantina), Prof Alan Rowan (AIBN), Dr Amanda Kijas (AIBN).

Our Vascular program is led by vascular surgeons Dr Jason Jenkins and Dr Nigel Pinto. It is focussed on the following collaborative projects:

  • Advanced manufacturing of bioresorbable stents: process and materials, deployment mechanisms, and antimicrobial effects of graphene.
  • Soft robotic catheters for minimally invasive surgery: design and manufacturing process development.
  • Tissue engineering of vascular grafts.
  • Surgical training and simulation for treatment planning and skills development.

Our Urology program is led by urology surgeon Dr Nicholas Rukin. It is focussed on the following collaborative research projects:

  • 3D printing of patient-specific prostate anatomical models for surgical planning and patient communication.
  • Development of novel medical devices for urological equipment, including stents, prosthetic testicles, teaching apparatus and endourological equipment
  • 3D printing of meshes for tissue repair

Our Cancer Care program is led by medical physicist A/Prof Scott Crowe. It is focussed on the following collaborative projects:

  • 3D printing of patient specific bolus, shielding, positioning devices and brachytherapy applicators, using optical, CT and/or MRI based models.
  • Development of bespoke quality assurance phantoms for imaging and radiation dose measurements.
  • Development of improved cell culture vessels for accurate and repeatable radiation biology experiments.

2021 Programs

Our CranioFacial program is co-led by neurosurgeon Dr Michael Redmond and maxillofacial surgeon A/Prof Martin Batstone. This integrated program is focussed on two clinical streams.

 Neurosurgery and craniofacial reconstruction:

  • Virtual surgical planning (adults and paediatric)
  • Novel cranioplasty constructs (adults and paediatric)
  • High-fidelity simulation models
  • Medical education and training using surgical simulations.
  • Metro North HHS collaborators: Dr Michael Wagels, Dr Craig Winter, Dr Liam Maclachlan.
  • Qld Children’s Hospital collaborators: Dr Yun Phua, Dr Robert Campbell, Dr Michael Wagels.

 Maxillofacial and oro-dental reconstruction:

  • Large-volume craniofacial bone defects, acquired through trauma, malignancy, or loss of dentition
  • Congenital or acquired orofacial soft/hard tissue defects such as temporomandibular joint defects or orofacial clefts
  • Highly prevalent, chronic oro-dental inflammatory diseases, such as periodontitis and peri-implantitis
  • Congenital or acquired ocular, aural, or nasal defects.
  • UQ Academic Lead: Prof Saso Ivanovski.
  • Metro North HHS collaborators: Dr Michael Burgess, A/Prof David Thomson, Dr Alyssa Zhang.
  • Qld Children’s Hospital collaborators: Dr Benjamin Roberston, Dr Ghassan Idris.

Our Anaesthesia and Intensive Care (AIC) program is co-led by anaesthetist Dr Christopher Futter and intensivist Dr George Pang.

Program summary:

  • Advanced anatomical modelling and manufacturing for simulation and education
    • Anatomy phantoms: regional anaesthesia and airways
    • High fidelity simulation models
    • Virtual reality patient specific anatomy
  • Advanced patient positioning and protective equipment
    • Custom patient supports through 3D scanning
  • RBWH collaborator: Dr Marianne Kirrane.

 

Projects

Clinical Lead: Dr Marianne Kirrane

Staff Specialist, Intensive Care, RBWH

RBWH collaborators: Dr George Pang, Dr Chris Futter, Prof Fiona Coyer (QUT)

HBI collaborators: Mathilde Desselle, Dr David Forrestal, Dr Michael Wagels

CSDS collaborators: Luke Wainwright, Daniel Host, Joshua Drew

Proudly funded by: Metro North HHS SEED Grant

Watch the EPIIC video.

Many critically ill patients sustain pressure injuries, a skin injury caused by sustained forces of pressure and shear. Patients with severe acute lung disease, including COVID-19, are turned prone, or face down, as part of their treatment in ICU. This causes pressure injuries, particularly to the mouth, nose and ears. Long-term harm includes blindness from ocular pressure.

Through the EPIIC project we will develop locally designed and manufactured face cushions that conform to each patient’s characteristic features better, using modern skin compatible materials.

Watch the PPE video.

  • Personal protective equipment (PPE) is critical to protect hospital staff and enable effective treatment of infectious patients, such as those with COVID- 19. PPE includes fluid resistant gowns, surgical masks, protective eyewear and gloves.
  • Due to the pandemic, MNHHS facilities are experiencing increased use of PPE. To respond to this risk, the Herston Biofabrication Institute is using advanced manufacturing to develop novel face shields, respirator masks and other devices.
  • 18,000 3D printed face shields were crowdsourced in 4 weeks and the team is progressing the development of an N95/P2 respirator masks, as well as disposable gowns. The Institute is also collaboratively developing new simulation and evaluation methods to test the efficacy of novel PPE with a dedicated clinical advisory group.
  • Key partners: Digital Metro North, the Clinical Skills Development Service, COVID-SOS, The University of Queensland, QUT, Woodford Correctional Services and the Arc Hardware Incubator.
  • Key MNHHS team members: Mathilde Desselle, Dr Marianne Kirrane, Dr David Forrestal, Nerys Brackman, Dr Clair Sullivan, Dr Michael Wagels.

PARM-VR: Pain Augmented Relief Method – Virtual Reality (VR). Supported by the Jamieson Trauma Institute and QUT, this project investigates the co-design of an innovative VR environment in health. It engages adult burns survivors and adolescents and young adults (AYAs) with cancer in the management of pain, anxiety and boredom through distraction and mindfulness. The app is currently in development and will be trialled in pilot studies in 2021.

  • Key MNHHS team members: Mathilde Desselle, Lucy Holland, Dr Jason Brown, A/Prof Paul Gray, Andrea McKittrick, Christine Cotter, A/Prof Glen Kennedy, Stephen Poyser.
  • Key partners: RBWH Professor Stuart Pegg Adult Burns Centre, RBWH Professor Tess Cramond Multidisciplinary Pain Centre, RBWH Cancer Care Services, Queensland Youth Cancer Service, PAH, Clinical Skills Development Service, QUT.

REHAB-VR is investigating patient engagement through gaming, hand tracking and immersive technologies as adjuncts to upper-limb rehabilitation.

  • Key MNHHS team members: Andrea McKittrick, Giovanna Tornatore, Sue Laracy, Mathilde Desselle.
  • Key partners: RBWH Geriatric and Rehabilitation Unit, RBWH Professor Stuart Pegg Adult Burns Centre, The University of Queensland, QUT.

Herston Biofabrication Institute (HBI)

Level 12, Block 7 Royal Brisbane and Women's Hospital HERSTON QLD 4029

Email: hbi@health.qld.gov.au