{"id":2739,"date":"2026-06-30T14:45:37","date_gmt":"2026-06-30T04:45:37","guid":{"rendered":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/?page_id=2739"},"modified":"2026-07-01T12:51:36","modified_gmt":"2026-07-01T02:51:36","slug":"skin-regeneration","status":"publish","type":"page","link":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/research\/skin-regeneration","title":{"rendered":"Skin Regeneration"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_3_4 3_4 fusion-three-fourth fusion-column-first\" style=\"--awb-bg-size:cover;width:75%;width:calc(75% - ( ( 4% ) * 0.75 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\"><h1 class=\"fusion-title-heading title-heading-left\">Skin Regeneration<\/h1><\/div><div class=\"fusion-text fusion-text-1\"><div id=\"attachment_668\" style=\"width: 210px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-668\" class=\"wp-image-668 size-fusion-200 lazyload\" data-src=\"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-200x200.jpg\" alt=\"\" width=\"200\" height=\"200\" data-srcset=\"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-66x66.jpg 66w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-150x150.jpg 150w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-200x200.jpg 200w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-300x300.jpg 300w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-400x400.jpg 400w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-600x600.jpg 600w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-768x768.jpg 768w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-800x800.jpg 800w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-1024x1024.jpg 1024w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-1200x1200.jpg 1200w, https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2020\/12\/BROWN_Jason_large_2800x2800-1-1536x1536.jpg 1536w\" data-sizes=\"(max-width: 200px) 100vw, 200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 200px; --smush-placeholder-aspect-ratio: 200\/200;\" \/><p id=\"caption-attachment-668\" class=\"wp-caption-text\">Dr Jason Brown<\/p><\/div>\n<p>Dr Jason Brown (Metro North), in collaboration with Dr Amanda Kjas (UQ), is advancing biofabrication-enabled skin regeneration strategies for burns and complex wounds. This work targets improved healing, reduced complications and better long-term functional outcomes.<\/p>\n<h3>Clinical challenge<\/h3>\n<p>Current treatments, including skin grafts and dermal substitutes, often fail to fully restore normal skin structure and function due to poor vascularisation, infection risk and variable long- term outcomes. These limitations contribute to ongoing morbidity, scarring, functional impairment, and high health system costs, highlighting the need for more effective regenerative approaches.<\/p>\n<h3>Clinical application<\/h3>\n<div id=\"attachment_2749\" style=\"width: 232px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-2749\" class=\"wp-image-2749 size-full lazyload\" data-src=\"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-content\/uploads\/sites\/16\/2026\/06\/amanda-kjas.jpeg\" alt=\"\" width=\"222\" height=\"222\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 222px; --smush-placeholder-aspect-ratio: 222\/222;\" \/><p id=\"caption-attachment-2749\" class=\"wp-caption-text\">Dr Amanda Kjas<\/p><\/div>\n<p>Advancing clinically relevant skin regeneration strategies through biofabrication to address severe burns, with the goal of improving healing and long-term functional recovery. Grounded in clinically embedded research, the program integrates advanced skin models, biomaterials, and translational burns care. This work is supported by high-impact clinical research, including the development of biodegradable matrices and the application of 3D-scanned technologies for scar management and patient-specific interventions.<\/p>\n<h3>Impact<\/h3>\n<p>The impact of this research lies in its progression toward clinically deployable solutions that better replicate natural skin function. By connecting laboratory innovation with real-world burns care, the program is strengthening Queensland&#8217;s capability in skin biofabrication, regenerative medicine and trauma care. It also contributes to improved clinical pathways that aim to enhance healing outcomes, reduce complications and support long- term recovery for patients withcomplex skin injuries.<\/p>\n<\/div><div class=\"fusion-text fusion-text-2\"><h2>Publications<\/h2>\n<ul>\n<li>Mostina M, Sun J, Sim SL, et al. Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells. Advanced healthcare materials 2025;14:e02108.<\/li>\n<li>Ahmed I, Sun J, Brown J, Khosrotehrani K, Shafiee A. An optimized protocol for generating appendage-bearing skin organoids from human-induced pluripotent stem cells. Biol Methods Protoc 2024;9:bpae019.<\/li>\n<li>Shafiee A, Sun J, Ahmed IA, et al. Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells. Small 2024;20:e2304879.<\/li>\n<li>Sun J, Ahmed I, Brown J, Khosrotehrani K, Shafiee A. The empowering influence of air-liquid interface culture on skin organoid hair follicle development. Burns Trauma 2025;13:tkae070.<\/li>\n<li>Hosseini M, Brown J, Shafiee A. Strategies to Induce Blood Vessel Ingrowth into Skin Grafts and Tissue-Engineered Substitutes. Tissue Eng Part C Methods 2022;28:113-26.<\/li>\n<li>Betar N, Donovan M, Tyack Z, et al. Recovery in patients undergoing ablative fractional carbon dioxide laser for adult hypertrophic burn scars: A longitudinal cohort study. Burns 2025;51:107300.<\/li>\n<li>Betar N, Maher D, Wheatley L, Barker T, Brown J. Clinical outcomes and resource utilisation in patients with major burns treated with NovoSorb(R) BTM. Burns 2023;49:1663-9.<\/li>\n<li>Lo CH, Brown JN, Dantzer EJG, et al. Wound healing and dermal regeneration in severe burn patients treated with NovoSorb(R) Biodegradable Temporising Matrix: A prospective clinical study. Burns 2022;48:529-38.<\/li>\n<li>Kittrick AM, Brown J. 110 Implementation of 3D Technology for Management of Facial Scars Across the Spectrum of Care. Journal of Burn Care &amp; Research 2025;46:S87-S.<\/li>\n<\/ul>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div>\n<div class=\"fusion-text fusion-text-3\"><div class=\"strong-view strong-view-id-1 modern wpmtst-modern\" data-count=\"1\"><div class=\"strong-content strong-normal columns-1\"><div class=\"wpmtst-testimonial testimonial post-2742\"><div class=\"wpmtst-testimonial-inner testimonial-inner\"><div   class=\"wpmtst-testimonial-content  testimonial-content\"><p>As a burns survivor and consumer advocate, I strongly support investment in skin biofabrication research. Healing doesn\u2019t end when the wound closes: many of us live with lifelong scarring, limited mobility, and ongoing surgeries. Biofabrication that can regenerate skin closer to natural human tissue offers real hope for better long\u2011term recovery.<\/p><\/div><div class=\"wpmtst-testimonial-field testimonial-field testimonial-name\">Trevor<\/div><div class=\"clear\"><\/div><\/div><\/div><\/div><\/div>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_4 1_4 fusion-one-fourth fusion-column-last rhs-col fusion-no-small-visibility\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;width:25%;width:calc(25% - ( ( 4% ) * 0.25 ) );\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last contact-us\" style=\"--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-bottom:0px;--awb-padding-left:0px;--awb-bg-size:cover;--awb-margin-bottom:0px;width:100%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-4\"><h2>Metro North Health, Herston Biofabrication Institute (HBI)<\/h2>\n<p>Level 12, Block 7<br \/>\nRoyal Brisbane and Women\u2019s Hospital<br \/>\nHERSTON QLD 4029<\/p>\n<p><strong>For General Requests: <\/strong><a href=\"mailto:hbi@health.qld.gov.au\">hbi@health.qld.gov.au<\/a><\/p>\n<p><strong>For Clinical Trials:\u00a0 <\/strong><a href=\"mailto:hbiclinicaltrials@health.qld.gov.au\">hbiclinicaltrials@health.qld.gov.au<\/a><strong><br \/>\n<\/strong><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div>\n<div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":0,"parent":62,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","footnotes":""},"tags":[],"class_list":["post-2739","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/pages\/2739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/comments?post=2739"}],"version-history":[{"count":10,"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/pages\/2739\/revisions"}],"predecessor-version":[{"id":2840,"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/pages\/2739\/revisions\/2840"}],"up":[{"embeddable":true,"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/pages\/62"}],"wp:attachment":[{"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/media?parent=2739"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/metronorth.health.qld.gov.au\/herston-biofabrication-institute\/wp-json\/wp\/v2\/tags?post=2739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}