Biofabrication
Injury Scanning and Scaffold Design
Patient injury data is scanned using clinical CT, MRI, 3D laser scanning or 3D reconstruction from photographs. Our software uses this data to design the shape of the tissue construct to match the specific needs of the patient. The software also provides a very high degree of control over the fabrication process.
3D Biofabrication Using Melt Electrospinning Writing
Our proprietary biofabrication technology is designed to rapidly fabricate morphologically accurate tissue engineering scaffolds. Using very high electric fields, we construct complex shapes out of biocompatible polymer fibres that are much thinner than a human hair. The implanted scaffolds completely dissolve as the tissue grows through, leaving the patient’s own restored tissue.
Scaffold and Tissue Analysis Technology
We have developed advanced tissue analysis techniques such as magnetic resonance micro-imaging techniques to non-invasively investigate the evolution of the nutrient and oxygen pathways deep within the tissue laden scaffolds. This helps us develop predictive models to produce scaffolds with complex architectures and integrated micro-channels for successful cell growth.
We are applying these techniques to the development of bone and cartilage tissue scaffolds.
Chief Investigators
Team
- Dr Sean Powell
- Dr Mark Allenby
- Dr Cynthia Wong
- Sam Liao
- Dr David Forrestal
- Matthew Lanaro
- Naomi Paxton
- Rena Cruz
- Madison Ainsworth
- Maureen Ross
- Dr Edward Ren
Publications
- Lanaro, Matthew, Booth, Larnii, Powell, Sean, & Woodruff, Mia (2018) Electrofluidodynamic technologies for biomaterials and medical devices: melt electrospinning. In Guarino, V & Ambrosio, L (Eds.) Electrofluidodynamic technologies (EFDTs) for biomaterials and medical devices (1st Edition): Principles and advances (Woodhead Publishing Series in Biomaterials). Woodhead Publishing, United Kingdom, pp. 37-69.
View on ePrints - Lanaro, Matthew, Forrestal, David, Scheurer, Stefan, Slinger, Damien, Liao, Sam, Powell, Sean, & Woodruff, Mia (2017) 3D printing complex chocolate objects: Platform design, optimization and evaluation. Journal of Food Engineering, 215, pp. 13-22.
View on ePrints - Forrestal, David, Klein, Travis, & Woodruff, Mia (2017) Challenges in engineering large customized bone constructs. Biotechnology and Bioengineering, 114(6), pp. 1129-1139.
View on ePrints - Singh, Daniel, Barani Lonbani, Zohreh, Woodruff, Mia, Parker, Tony, Steck, Roland, & Peake, Jonathan (2017) Effects of topical icing on inflammation, angiogenesis, revascularization and myofiber regeneration in skeletal muscle following contusion injury. Frontiers in Physiology, 8, Article number: 93 1-39.
View on ePrints - Liao, Sam, Simpson, Benjamin, Neidlin, Michael, Kaufmann, Tim, Li, Zhiyong, Woodruff, Mia, & Gregory, Shaun (2016) Numerical prediction of thrombus risk in an anatomically dilated left ventricle: the effect of inflow cannula designs. BioMedical Engineering OnLine, 15(S2), Article number: 136 587-604.
View on ePrints - Liao, Sam, Langfield, Brendan, Ristovski, Nikola, Theodoropoulos, Christina, Hardt, Jake, Blackwood, Keith, Yambem, Soniya, Gregory, Shaun, Woodruff, Mia, & Powell, Sean (2016) Effect of humidity on melt electrospun polycaprolactone scaffolds. BioNanoMaterials, 17(3 – 4), pp. 173-178.
View on ePrints - Paxton, Naomi, Powell, Sean, & Woodruff, Mia (2016) Biofabrication: The future of regenerative medicine. Techniques in Orthopaedics, 31(3), pp. 190-203.
View on ePrints - Poh, Su, Hutmacher, Dietmar, Holzapfel, Boris, Solanki, Anu, & Woodruff, Mia (2016) Data for accelerated degradation of calcium phosphate surface-coated polycaprolactone and polycaprolactone/bioactive glass composite scaffolds. Data in Brief, 7, pp. 923-926.
View on ePrints - Berner, Arne, Henkel, Jan, Woodruff, Mia, Saifzadeh, Siamak, Kirby, Giles, Zaiss, Sascha, Gohlke, Jan, Reichert, Johannes, Nerlich, Michael, Schuetz, Michael, & Hutmacher, Dietmar (2017) Scaffold-cell bone engineering in a validated preclinical animal model: Precursors vs differentiated cell source. Journal of Tissue Engineering and Regenerative Medicine, 11(7), pp. 2081-2089.
View on ePrints - Bartnikowski, Michal, Akkineni, Ashwini Rahul, Gelinsky, Michael, Woodruff, Mia, & Klein, Travis (2016) A hydrogel model incorporating 3D-plotted hydroxyapatite for osteochondral tissue engineering. Materials, 9(4), Article number: 285 1-17.
View on ePrints - Liao, Sam, Theodoropoulos, Christina, Blackwood, Keith, Woodruff, Mia, & Gregory, Shaun (2018) Melt electrospun bilayered scaffolds for tissue integration of a suture-less inflow cannula for rotary blood pumps. Artificial Organs, 42(5), pp. 43-54.
View on ePrints - Ristovski, Nikola, Bock, Nathalie, Liao, Sam, Powell, Sean, Ren, Jiongyu Edward, Kirby, Giles, Blackwood, Keith, & Woodruff, Mia (2015) Improved fabrication of melt electrospun tissue engineering scaffolds using direct writing and advanced electric field control. Biointerphases, 10(1), Article number: 011006 1-10.
View on ePrints - Ren, Jiongyu Edward, Blackwood, Keith, Doustgani, Amir, Poh, Su, Steck, Roland, Stevens, Molly, & Woodruff, Mia (2014) Melt-electrospun polycaprolactone-strontium substituted bioactive glass scaffolds for bone regeneration. Journal of Biomedical Materials Research – Part A, 102(9), pp. 3140-3153.
View on ePrints - Powell, Sean, Ristovski, Nikola, Liao, Sam, Blackwood, Keith, Woodruff, Mia, & Momot, Konstantin (2014) Characterization of the microarchitecture of direct writing melt electrospun tissue engineering scaffolds using diffusion tensor and computed tomography microimaging. 3D Printing and Additive Manufacturing, 1(2), pp. 95-103.
View on ePrints - Berner, Arne, Woodruff, Mia, Lam, Christopher, Arafat, M.T., Saifzadeh, Siamak, Steck, Roland, Ren, Jiongyu Edward, Nerlich, Michael, Ekaputra, Andrew Krishna, Gibson, Ian, & Hutmacher, Dietmar (2014) Effects of scaffold architecture on cranial bone healing. International Journal of Oral and Maxillofacial Surgery, 43(4), pp. 506-513.
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Metro North Health, Herston Biofabrication Institute (HBI)
Level 12, Block 7 Royal Brisbane and Women's Hospital HERSTON QLD 4029
Email: hbi@health.qld.gov.au