Cardiology publications

The research conducted by Cardiology Clinical Research Centre (CCRC)  has contributed to the worldwide bank of knowledge and rapid evolution of technology in improving the longevity and quality of patients’ lives. In the last five years, the design and development of various percutaneous approach aortic valve,  mitral clip and shunt devices implantation to treat patients with severe aortic stenosis, severe mitral regurgitation and diastolic heart failure have been approved for commercial application. This advancement is becoming the new global standard of care.

Clinical outcomes for the various valves have recently been published with promising results in terms of paravalvular regurgitation and accurate valve positioning. Another exciting step forwarding is the utilisation of ground breaking technology to monitor heart failure patients remotely within the Asia-Pacific region.

List of publications

Allahwala UK, Hansen PS, Danson EJ, Straiton N, Sinhal A, Walters DL, et al. Transcatheter aortic valve implantation: Current trends and future directions. Future Cardiology. 2016;12(1):69-85.

Beasley R, Chien J, Douglas J, Eastlake L, Farah C, King G, et al. Target oxygen saturation range: 92-96% Versus 94-98. Respirology (Carlton, Vic). 2016.

Black P, Savage M, Murdoch D, Raffel C, Walters D. Effectiveness of utilising aortic regurgitation (AR) index to define peri-prosthetic aortic regurgitation (PERIAR) severity in transcatheter aortic valve implantation (TAVI) patients. Heart Lung and Circulation. 2016;25:S173-S4.

Burkhoff D, Muller D, Walters D, Neuzeil P, Post M, Lang I, et al. Baseline haemodynamic characteristics of patients in the REDUCE elevated Left Atrial Pressure in patients with Heart Failure (REDUCE LAP-HF) trial. EuroIntervention. 2016:380.

Burkhoff D, Muller D, Walters D, Neuzil P, Post MC, Lang I, et al. Baseline hemodynamic characteristics of patients in the REDUCE elevated left atrial pressure in patients with heart failure trial. European Heart Journal. 2016;37:120-1.

Challa A, Markham R, Hlaing S, Kyranis S, Murdoch D, Savage M, et al. Impact of frailty on 30-day outcomes in patients undergoing transcatheter aortic valve replacement. Heart Lung and Circulation. 2016;25:S178.

Crowhurst, J. A., K. K. Poon, D. Murdoch, A. Incani, O. C. Raffel, A. Liddicoat and D. Walters (2015). “The effect of X-ray beam distortion on the Edwards Sapien XT(™) trans-catheter aortic valve replacement prosthesis.” Journal Of Medical Radiation Sciences 62(4): 239-245.

Crowhurst, J. A., M. Savage, V. Subban, A. Incani, O. C. Raffel, K. Poon, D. Murdoch, R. Saireddy, A. Clarke, C. Aroney, N. Bett and D. L. Walters (2016). “Factors Contributing to Acute Kidney Injury and the Impact on Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement.” Heart, Lung & Circulation 25(3): 282-289.

Crowhurst J, Whitby M, Murdoch D, Raffel C, Walters D. Factors contributing to patient and operator radiation dose during cardiac angiography. Journal of Medical Radiation Sciences. 2016;63:78

Crowhurst J, Whitby M, Murdoch D, Poon K, Shaw E, Gaikwad N, et al. New generation X-ray technology reduces radiation dose whilst improving image quality during diagnostic coronary angiography and intervention. Heart Lung and Circulation. 2016;25:S183.

Daniel Burkhoff D, Muller D, Walters D, Neuzil P, Post MC, Lang I, et al. Baseline hemodynamic characteristics of patients in the REDUCE elevated left atrial pressure in patients with heart failure trial. European Journal of Heart Failure. 2016;18:510.

Davies JE, Sen S, Dehbi HM, Al-Lamee R, Petraco R, Nijjer SS, Bhindi R, Lehman SJ, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Canas Silva P, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp AS, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J. Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI. N Engl J Med. 2017 Mar 18. doi: 10.1056/NEJMoa1700445. [Epub ahead of print] PubMed PMID: 28317458.

Fanning, J. P., J. Nyong, I. A. Scott, C. N. Aroney and D. L. Walters (2016). “Routine invasive strategies versus selective invasive strategies for unstable angina and non-ST elevation myocardial infarction in the stent era.” The Cochrane Database Of Systematic Reviews(5): CD004815.

Fanning, J. P., A. J. Wesley, D. L. Walters, E. M. Eeles, A. G. Barnett, D. G. Platts, A. J. Clarke, A. A. Wong, W. E. Strugnell, C. O’Sullivan, O. Tronstad and J. F. Fraser (2016). “Neurological Injury in Intermediate-Risk Transcatheter Aortic Valve Implantation.” Journal of the American Heart Association 5(11): 1-14.

Fanning J, Wesley A, Walters D, Platts D, Fraser J. Neurological injury complicates the majority of transcatheter aortic valve implantation (TAVI) procedures. Anaesthesia and Intensive Care. 2016;44(2):305.

Fanning J, Wesley A, Walters D, Wong A, Fraser J. Topographical distribution of cerebral infarction associated with transcatheter aortic valve implantation (TAVI). Cerebrovascular Diseases. 2016;42:26.

Fletcher M, O’Rourke R, Neill J, Chan J, Walters D, Hamilton-Craig C. Accuracy of coronary CT angiography is not predicted by case volume of the service: An analysis of 1025 CCTA scans. Heart Lung and Circulation. 2016;25:S210-S1.

Gaikwad N, Khaled B, Kyranis S, Savage M, Shaw E, Robinson B, et al. Tavi in the younger population: A comparison between <75 year and >75 year cohorts. Heart Lung and Circulation. 2016;25:S200.

Gaikwad N, Townsend S, Poon K, Raffel C, Hamilton-Craig C, Scalia G, et al. Tricuspid valvuloplasty is an effective treatment for bioprosthetic tricuspid valve stenosis. Heart Lung and Circulation. 2016;25:S206.

Goldstein J, Lakshmanan A, Walters D, Zhang Z. Establishing an “antegrade only” chronic total occlusion intervention program without onsite surgical backup at Mackay base hospital, Queensland and the result of the first 8 cases. Heart Lung and Circulation. 2016;25:S175.

Habibian M, Batra R, Mengel C, Sweeny A, Walters D. Cardiologists beware: An unusual cause of myocardial infarction after aortic valve replacement. Heart Lung and Circulation. 2016;25:S35.

Hamilton-Craig C, Bhuiyan K, Branch K, Neill J, Chan J, Walters D, et al. CT fractional flow reserve improves the accuracy of CT coronary angiography in the emergency department – A substudy of ctcompare. Heart Lung and Circulation. 2016;25:S224.

Hasenfuß, G., C. Hayward, D. Burkhoff, F. E. Silvestry, S. McKenzie, F. Gustafsson, F. Malek, J. Van der Heyden, I. Lang, M. C. Petrie, J. G. F. Cleland, M. Leon and D. M. Kaye (2016). “A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial.” Lancet (London, England) 387(10025): 1298-1304.

He, C., G. Scalia, D. L. Walters and A. Clarke (2016). “Transapical Transcatheter Mitral Valve-in-Valve Implantation Using an Edwards Sapien 3 Valve.” Heart, Lung & Circulation.Heersink, D., D. Murdoch, J. Humphries and D. L. Walters (2016). “Left Atrial Appendage Closure Device Implantation After Percutaneous Atrial Septal Defect Closure.” JACC. Cardiovascular Interventions 9(10): e95-e96.

Heersink, D., D. Murdoch, J. Humphries and D. L. Walters (2016). “Left Atrial Appendage Closure Device Implantation After Percutaneous Atrial Septal Defect Closure.” JACC. Cardiovascular Interventions 9(10): e95-e96.

Jahangiri, B. and O. C. Raffel (2016). “IMAGES IN CLINICAL MEDICINE. Enlarged Right Atrium.” The New England Journal Of Medicine 375(6): e7-e7.

Jauncey, P., S. McKenzie, R. Corpus, K. M. Fong and D. L. Walters (2016). “General medicine Indigenous outreach registrar training in rural Queensland.” The Medical Journal Of Australia 205(5): 237-237.

Kahrom A, Markham R, Mandala A, Gaikwad N, Kyranis S, Murdoch D, et al. J-CTO score in predicting procedural success and outcomes at 12 months: A single centre registry. Heart Lung and Circulation. 2016;25:S180.

Kaye, D. M., G. Hasenfuß, P. Neuzil, M. C. Post, R. Doughty, J. N. Trochu, A. Kolodziej, R. Westenfeld, M. Penicka, M. Rosenberg, A. Walton, D. Muller, D. Walters, J. Hausleiter, P. Raake, M. C. Petrie, M. Bergmann, G. Jondeau, T. Feldman, D. J. Van Veldhuisen, P. Ponikowski, F. E. Silvestry, D. Burkhoff and C. Hayward (2016). “One-Year Outcomes after Transcatheter Insertion of an Interatrial Shunt Device for the Management of Heart Failure with Preserved Ejection Fraction.” Circulation: Heart Failure 9(12).

Khan E, Brieger D, Amerena J, Atherton J, Farshid A, Ilton M, et al. Gender differences in hospital management of ST-elevation myocardial infarction patients. Heart Lung and Circulation. 2016;25:S46-S7.

Kyranis, S., R. Markham, D. Platts, D. Murdoch and D. Walters (2016). “Transcatheter aortic valve implantation using the Lotus valve system in severe aortic stenosis in an orthotopic heart transplant patient.” International Journal Of Cardiology 207: 192-193.

Kyranis S, Markham R, Shaw E, Savage M, Crowhurst J, Murdoch D, et al. Thrombocytopenia post transcatheter aortic valve insertion: A single centre experience. Heart Lung and Circulation. 2016;25:S204.

Kyranis S, Murdoch D, Walters D. Transient cortical blindness post percutaneous balloon valvuloplasty. Heart Lung and Circulation. 2016;25:S205.

Lam K, Savage M, Murdoch D, Raffel C, Walters D, Paitry S. Realworld comparison of fractional flow reserve (FFR) and instantaneouswave-free ration (IFR) in a single centre. Heart Lung and Circulation. 2016;25:S262.

Lam K, Savage M, Murdoch D, Raffel C, Walters D, Shaw E, et al. Contemporary fractional flow reserve (FFR) utilisation in a large Australian tertiary centre. Heart Lung and Circulation. 2016;25:S260.

Lobo M, Montarello J, Saxena M, Jain A, Walters D, Pincus M, et al. Renal denervation using the EnligHTN renal denervation system in alternative hypertensive populations: 24-month results from the EnligHTN II study. EuroIntervention. 2016:467.

Lobo, M. D., J. Montarello, M. Saxena, A. Jain, D. Walters, M. Pincus, C. Tsioufis, V. Papademetriou and S. Worthley (2016). “[OP.4C.04] SAFETY AND PERFORMANCE OF THE ENLIGHTN RENAL DENERVATION SYSTEM IN PATIENTS WITH DRUG-RESISTANT HYPERTENSION: POOLED ANALYSES FROM THE ENLIGHTN 1, 2 AND 3 TRIALS.” Journal Of Hypertension 34 Suppl 2: e48-e48.

Markham R, Challa A, Hlaing S, Kyranis S, Murdoch D, Savage M, et al. Comparative outcomes of balloon, mechanical and self-expanding devices in transcatheter aortic valve replacement. Heart Lung and Circulation. 2016;25:S169.

Markham R, Challa A, Kyranis S, Gaikwad N, Shaw E, Vaishnav M, et al. Transcatheter valve-in-valve implantation in a stenosed bioprosthetic tricuspid valve: A case report. Heart Lung and Circulation. 2016;25:S205.

Markham R, Challa A, Kyranis S, Nicolae M, Murdoch D, Savage M, et al. Outcomes Following Melody Transcatheter Pulmonary Valve Implantation for Right Ventricular Outflow Tract Dysfunction in Repaired Congenital Heart Disease: First Reported Australian Single Centre Experience. Heart Lung and Circulation. 2017.

Markham R, Challa A, Kyranis S, Mandala A, Hanna J, Latona J, et al. Outcomes after transcatheter pulmonary valve (Melody) implantation in a tertiary Australian centre. Heart Lung and Circulation. 2016;25:S185.

Markham R, Kahrom A, Mandala A, Gaikwad N, Kyranis S, Murdoch D, et al. Radiation during percutaneous coronary interventions in chronic coronary total occlusions. Heart Lung and Circulation. 2016;25:S193.

Markham, R., D. Murdoch, J. Govindasamy, C. Raffel and D. Walters (2016). “Shirtfront Myocardial Infarction: Traumatic Coronary Plaque Disruption Secondary to a Football Tackle.” Heart Lung and Circulation.

Markham, R., D. Murdoch, D. L. Walters and C. Hamilton-Craig (2016). “Author reply.” Internal Medicine Journal 46(8): 992-993.

Markham, R., D. Murdoch, D. L. Walters and C. Hamilton-Craig (2016). “Coronary computed tomography angiography and its increasing application in day to day cardiology practice.” Internal Medicine Journal 46(1): 29-34.

Mengel C, Adusumalli S, Bhuiyan K, Habibian M, Walters D, Poon K. Techniques for the percutaneous retrieval of embolised vascular devices. Heart Lung and Circulation. 2016;25:S200-S1.

Mengel C, Murdoch D, Walters D, Scalia G. Percutaneous salvage after partial avulsion of mitral clip repair. Heart Lung and Circulation. 2016;25:S188.

Meredith, I. T., D. L. Walters, N. Dumonteil, S. G. Worthley, D. Tchétché, G. Manoharan, D. J. Blackman, G. Rioufol, D. Hildick-Smith, R. J. Whitbourn, T. Lefèvre, R. Lange, R. Müller, S. Redwood, T. E. Feldman, D. J. Allocco and K. D. Dawkins (2016). “1-Year Outcomes With the Fully Repositionable and Retrievable Lotus Transcatheter Aortic Replacement Valve in 120 High-Risk Surgical Patients With Severe Aortic Stenosis: Results of the REPRISE II Study.” JACC. Cardiovascular Interventions 9(4): 376-384.

Minami, Y., Z. Wang, A. D. Aguirre, S. Lee, S. Uemura, T. Soeda, R. Vergallo, O. C. Raffel, P. Barlis, T. Itoh, H. Lee, J. Fujimoto and I. K. Jang (2016). “Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: A comparison between Xience v and Resolute Integrity stents.” Coronary Artery Disease 27(1): 19-28.

Muller DW, Farivar RS, Jansz P, Bae R, Walters D, Clarke A, Grayburn PA, Stoler RC, Dahle G, Rein KA, Shaw M, Scalia GM, Guerrero M, Pearson P, Kapadia S, Gillinov M, Pichard A, Corso P, Popma J, Chuang M, Blanke P, Leipsic J, Sorajja P; Tendyne Global Feasibility Trial Investigators.. Transcatheter Mitral Valve Replacement for Patients With Symptomatic Mitral Regurgitation: A Global Feasibility Trial. J Am Coll Cardiol. 2017 Jan 31;69(4):381-391. doi: 10.1016/j.jacc.2016.10.068. Epub 2016 Dec 28. PubMed PMID: 28040318

Muller D, Sorajja P, Walters D, Grayburn P, Dahle G, Blanke P, et al. Transcatheter mitral valve replacement for severe mitral regurgitation: The TENDYNE early feasibility trial. EuroIntervention. 2016:365.

Paitry S, Savage M, Murdoch D, Raffel C, Walters D. Radial versus femoral access in ST-segment elevation myocardial infarction patients treated by primary percutaneous coronary intervention. Heart Lung and Circulation. 2016;25:S192.

Paitry S, Savage M, Murdoch D, Raffel C, Walters D. Use of drug-eluting versus bare metal stents in patientswith ST-segment elevation myocardial infarction. Heart Lung and Circulation. 2016;25:S207

Scalia GM, Scalia IG, Kierle R, Beaumont R, Cross DB, Feenstra J, Burstow DJ, Fitzgerald BT, Platts DG. ePLAR – The echocardiographic Pulmonary to Left Atrial Ratio – A novel non-invasive parameter to differentiate pre-capillary and post-capillary pulmonary hypertension. Int J Cardiol. 2016 Jun 1;212:379-86. doi: 10.1016/j.ijcard.2016.03.035. Epub 2016 Mar 19. PubMed PMID: 27061467.

Shaw E, Raffel O, Poon K, Murdoch D, Markham R, Gaikwad N, et al. Solopath sheath use during transfemoral transcatheter aortic valve replacement. Heart Lung and Circulation. 2016;25:S198.

Shiino K, Yamada A, Walters D, Hamilton-Craig C, Platts DG, Burstow D, et al. Short-term effects of transcatheter aortic valve implantation (TAVI) on left ventricular transmural mechanics using multi-layer speckle tracking echocardiography. European Heart Journal. 2016;37:462.

Sievert H, Schofer J, Ormiston J, Hoppe UC, Meredith IT, Walters DL, et al. Bipolar radiofrequency renal denervation with the Vessix catheter in patients with resistant hypertension: 2-year results from the REDUCE-HTN trial. Journal of Human Hypertension. 2017;31(5):366-8.

Subban, V., D. Murdoch, M. L. Savage, J. Crowhurst, R. Saireddy, K. K. Poon, A. Incani, N. Bett, D. J. Burstow, G. M. Scalia, A. Clarke, O. C. Raffel, C. N. Aroney and D. L. Walters (2016). “Outcomes of transcatheter aortic valve implantation in high surgical risk and inoperable patients with aortic stenosis: a single Australian Centre experience.” Internal Medicine Journal 46(1): 42-51.

Subban V, Savage M, Crowhurst J, Robinson B, Poon K, Incani A, et al. Assessment of functional significance of coronary artery disease of indeterminate severity with fractional flow reserve in patients with aortic stenosis undergoing transcatheter aortic valve implantation. Heart Lung and Circulation. 2016;25:S31.

Taylor, C. M., H. Samardhi and H. M. Haqqani (2015). “Atrial tachycardias arising from the atrial appendages and aortic sinus of Valsalva.” Current Cardiology Reviews 11(2): 118-126.

Tay, E., N. Muda, J. Yap, D. W. M. Muller, T. Santoso, D. L. Walters, X. Liu, E. Yamen, P. Jansz, J. Yip, R. Zambahari, J. Passage, Z. P. Ding, J. a. Wang, G. Scalia, A. M. Soesanto and K. K. Yeo (2016). “The MitraClip Asia-Pacific registry: Differences in outcomes between functional and degenerative mitral regurgitation.” Catheterization And Cardiovascular Interventions: Official Journal Of The Society For Cardiac Angiography & Interventions 87(7): E275-E281.

Tjahjadi C, Wee Y, Clarke A, Raffel C, Poon K, Savage M, et al. The impact of transcatheter aortic valve implantation on anaemia in aortic stenosis. Heart Lung and Circulation. 2016;25:S202.

Tjahjadi C, Wee Y, Tesar P, Walters D, Bett N. The prevalence of anaemia in aortic stenosis. Heart Lung and Circulation. 2016;25:S280.

Tjahjadi C, Platts D, Walters D, Burstow D, Sedgwick J. The impact of transcoronary ablation of septal hypertrophy on diastology in hypertrophic obstructive cardiomyopathy. Heart Lung and Circulation. 2016;25:S254.

Walters D, Sinhal A, Ng M, Yong G, Jepson N, Worthley S, et al. SOLACE AU registry: Interim results at one year of the edwards SAPIEN XT TM transcatheter heart valve in intermediate risk patients with severe aortic stenosis in Australia. Heart Lung and Circulation. 2016;25:S197.

Worthley S, Montarello J, Saxena M, Jain A, Walters D, Pincus M, et al. Safety and performance of the EnligHTN renal denervation system in patients with drug-resistant hypertension: Pooled analyses from the EnligHTN 1, 2 and 3 trials. EuroIntervention. 2016:468.

Yates, D. J., M. L. Savage, D. L. Walters and O. C. Raffel (2016). “Retrospective Study of First-Generation Drug-Eluting Stents, Second-Generation Drug-Eluting Stents and Non-Drug Eluting Stent Methods in the Treatment of Native Vessel In-Stent Restenosis in Real-World Clinical Practice.” Heart, Lung & Circulation 25(4): 342-351.

Yeaw, X., D. J. Murdoch, V. Wijesekera, J. F. Sedgwick, C. M. Whight, P. G. Pohlner, O. C. Raffel and D. L. Walters (2016). “Comparison of surgical repair and percutaneous stent implantation for native coarctation of the aorta in patients ≥ 15 years of age.” International Journal of Cardiology 203: 629-631.

Find more published research by Cardiology Clinical Research Centre (CCRC) on PubMed.