The Prince Charles Hospital

I’m having my 1st Telehealth appointment with a dietitian on the 18th !! Great timing Metro North.

There’s a familiar face from my nursing nursing prac out west about 17 years ago! Way to go Kate

If only they'd make mobile xray machines too or i would have

Telehealths the best

Welcome my Travelled Mates from O/Seas.... 2023? that big loud noisy bird... the fake HAZZA.... LOVE SMILING< YOUR PICTURE ON FB IS AMAZING< > IM SO PROUD OF YOU ALL!!!! Mercinary tour SAVE OPOSSUM <THATCHA(ER) SCARRIE and COOi from BUCKIE PAL. RTHIEFS< HOME SAFE !!!!!!, those black HATS...... Grrrrrr glad to see the tail end of that!

TEPE RING..

www.ncbi.nlm.nih.gov/books/NBK304351/#:~:text=HUMAN%20IMMUNODEFICIENCY%20VIRUS,FOLLOW%20NCBI

human chromosome code for h.i.v dna simplex stylus siHIV-1 does not have a single fixed "code" for human chromosomes; instead, it integrates into host DNA across all 24 human chromosomes, showing a distinct preference for gene-dense regions on chromosomes 16, 17, 19, and 22.The terms you mentioned relate to viral phenotypes and genomic structures:Simplex/SI (Syncytia-Inducing): This refers to HIV strains (class X4) that use the CXCR4 co-receptor to enter T-cells. These strains cause host cells to fuse together into "syncytia," which is often associated with faster disease progression.Stylus/Psi (\(\Psi \)): This likely refers to the Psi (\(\Psi \)) region, a critical secondary structure in the viral RNA genome located at the 5′ end. It is the primary signal for "packaging" the viral genome into new virus particles.RefSeq Code: For scientific reference, the "master code" or standard genome sequence for HIV-1 (HXB2) is often identified by the accession number NC_001802.Key Locations and MarkersIntegration Hotspots: HIV preferentially targets active genes in the host genome to ensure efficient transcription of its own genes.Host Factors: The protein LEDGF/p75 acts as a "tether" that guides the HIV DNA to these gene-rich chromosomal locations.Genetic Structure: The viral genome itself is roughly 9.2 kilobases long and contains nine primary genes (gag, pol, env, tat, rev, nef, vif, vpr, and vpu).Are you looking for a specific genetic sequence or more information on how these syncytia-inducing strains affect the immune system?This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more10 sitesSpatial and Genomic Correlates of HIV-1 Integration Site TargetingIn the current study, we show that speckle and speckle-proximal regions strongly correlate with gene-dense regions on particular c...PubMed Central (PMC) (.gov)HUMAN IMMUNODEFICIENCY VIRUS-1 - NCBI - NIHHIV-1 can be assigned to one of three classes based on its ability to use the two co-receptors. Class R5 comprises the viruses tha...National Institutes of Health (.gov)Structure and genome of HIV - WikipediaHIV employs a sophisticated system of differential RNA splicing to obtain nine different gene products from a less than 10kb genom...WikipediaShow all

www.genome.jp/dbget-bin/www_bget?refseq:NC_001802#:~:text=Database%3A%20RefSeq%0AEntry,database%2...

In neuro-biochemical textbooks, the agents responsible for the formation and growth of "internal scars" (tubers), nodules, and polyp-like cysts are primarily regulators of cell growth, signaling, and vascular permeability.Based on your descriptions of "scars," "polyp-like tumors," and "silica hair/lung-like" structures, the key biochemical agents involved are:1. mTOR (Mammalian Target of Rapamycin)This is the "master switch" for cell growth. In conditions like Tuberous Sclerosis Complex (TSC), mutations in the TSC1 (Hamartin) or TSC2 (Tuberin) genes prevent these proteins from inhibiting mTOR.Action: Unregulated mTOR leads to the creation of "giant cells" and disorganized tissue "scars" (tubers).Tumour Growth: It drives the transformation of small nodules (SENs) into polyp-like tumors called SEGAs.Treatment: Drugs like Everolimus are used as biochemical "inhibitors" to turn off this growth signal.2. VEGF (Vascular Endothelial Growth Factor)This is the biochemical agent likely responsible for your description of the "minute major capillary".Action: VEGF is an extremely potent inducer of angiogenesis (the formation of new blood vessels) and edemagenesis (the leaking of fluid that creates cysts).Tumor Effect: High levels of VEGF create the conspicuous, large-diameter capillaries often seen in polyp-like brain tumors like SEGAs.3. Shh (Sonic Hedgehog) and Wnt SignalingThese pathways are the biochemical drivers for structures that look like "hair" or "lung/throat" tissue inside the brain.Cilia Formation: These signals are transduced through primary cilia (tiny hairs on cells). If these pathways are active in the wrong place, they can lead to the growth of ciliated cysts (which look like the throat lining) or dermoid cysts (which contain actual hair follicles)."Silica Hair": In Dermoid Cysts, the biochemical environment allows for the production of keratin and sebum, which can crystallise and give hair a stiff, silica-like appearance.4. Aquaporin-4 (AQP4)This is a water-channel protein found in the "scars" and surrounding brain tissue.Action: It regulates the flow of fluid in and out of the brain's internal spaces.Cyst Formation: When AQP4 is dysregulated (often in the "scar" tissue or glia), it contributes to the buildup of fluid that forms internal brain cysts.Feature MentionedPrimary Biochemical AgentRelated ConditionInternal Scars / TubersmTOR Pathway (TSC1/TSC2)Tuberous SclerosisMinute Major CapillaryVEGF (Vascular Growth Factor)SEGA / GliomasLung/Throat/CiliaShh & Wnt SignalingCiliated / Colloid CystsSilica Hair / KeratinKeratinocyte Growth FactorsDermoid CystsWould you like to focus on the biochemical markers used to detect these agents in a lab setting, such as S6 kinase or GFAP?13 sitesThe neuronal cilium – a highly diverse and dynamic organelle ...15 May 2024 — Primary cilia serve as signaling hubs during neuronal development by transducing various signaling pathways, including Hedgehog, N...ScienceDirect.comPrimary Cilia in Brain Development and Diseases - ScienceDirect15 Jan 2018 — In the brain, primary cilia play critical roles at various stages of neurogenesis, from early patterning, through the proliferatio...ScienceDirect.comPrimary cilia in neural development and disease - ScienceDirectDuring neural tube development, Shh signaling is mediated by a cilium-localized Ptch1–Smo receptor complex, which regulates the ph...ScienceDirect.comShow all

Thanks for the update Carolyn, and the encouraging smile despite all your trials.

Hope your feeling better soon

You are in a safe place I hope you get better soon 🙏🏽

You are at a wonderful hospital receiving excellent care.All the best with your recovery

Best place to be!

I had not heard of Rheumatic fever. Sorry to hear you are in hospital but glad you are getting good care.

❤️

Not very good rheumatic fever my mum apparently had it in her younger life and passed at 44yrs in 1992 at Prince Charles Hospital she had a valve replacement but her heart muscles were to weak to start her heart during the operation being so young it was hard losing her I feel there should be more awareness of Rheumatic Fever

Thinking of you ❤️

Michelle Elmer Michelle Crowe Elmer

minimalist here

Hay, hi fro me....