Queensland researchers identify a third type of twin

Most people have heard of two types of twins—colloquially referred to as identical (monozygotic) twins, and fraternal (dizygotic) twins.

As a world first, in a paper published in the New England Journal of Medicine, a team of researchers theorised a third, much rarer, form known as sesquizygotic twinning existed.

The research team included RBWH Maternal Fetal Medicine staff specialists Dr Renuka Sekar and Dr Johanna Laporte and genetic counsellor Pauline McGrath, cytogeneticist Dr Adayapalam Nandini, and geneticist Dr Michael Gabbett and QUT Professor Nick Fisk.

Monozygotic twins are genetically identical individuals from a single sperm and egg. Dizygotic twins share approximately 50 per cent of their DNA sequence identity (the same as full siblings).

The third postulated form-sesquizygosity-is where individuals share between 50 and 100 per cent of genetic identity.

The research came about when routine first-trimester ultrasounds scans of a 28-year-old Queensland woman showed unequivocally what was identical (monozygotic) twins. But at 14-weeks, further scans showed that one foetus appeared to be male, and the other female.

Genetic studies determined that the twins appeared to be neither identical nor fraternal.

Instead the twins were found to be 100 per cent maternally identical and 77.7 per cent paternally identical, meaning they shared an identical maternal DNA but two separate paternal sets of DNA.

The results were compared with data on fraternal (dizygotic) twins and large population-based sibling studies, which yielded no other evidence of sesquizygotic twins.

The researchers concluded that sesquizygosis-whereby twins are genetically identical to each other with respect to one parent but differ from each other by approximately 50 per cent with respect to the composition of DNA inherited from the other parent – is a third, and rare, form of twinning.

Genetically, sesquizygosis is on a continuum between monozygosis and dizygosis. It’s believed to occur when two paternal sperm fertilise the same maternal egg at a particular juncture, resulting in two paternal genomes and one maternal genome.

Image of Belinda Anderson and Ruby Raine
2019-11-07T14:04:13+10:007 November 2019|
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