Latest news
RBWH pharmacist unpacks the social media peptide hype
A fast-growing social media trend promoting injectable peptides is prompting warnings from health professionals who say many of these products are unregulated, poorly understood, and potentially dangerous.
What is obstetric medicine and why is it important?
You probably know what an obstetrician does, but do you know the role of an obstetric medicine specialist?
Maintaining memory with dignity
Preserving a good memory is a common health concern for people as they grow older.
RBWH remembers trailblazing cancer care volunteer
RBWH has unveiled a memorial to honour pioneering Aboriginal and Torres Strait Islander cancer support worker Maureen Kirk.
Events
Advanced Life Support - Level 1 Course
Date: 26 August 2026
Time: TBC
Venue: The Prince Charles Hospital
Level 1 courses are for those clinicians who want general competence in airway management and basic life support for a deteriorating patient and cardiac arrest. Suitable if you normally are part of team rather than the lead.
Advanced Life Support - Level 1 Course
Date: 9 September 2026
Time: TBC
Venue: The Prince Charles Hospital
Level 1 courses are for those clinicians who want general competence in airway management and basic life support for a deteriorating patient and cardiac arrest. Suitable if you normally are part of team rather than the lead.
Advanced Life Support - Level 1 Course
Date: 16 September 2026
Time: TBC
Venue: The Prince Charles Hospital
Level 1 courses are for those clinicians who want general competence in airway management and basic life support for a deteriorating patient and cardiac arrest. Suitable if you normally are part of team rather than the lead.
Masks are an important defence against respiratory illness and protection from dust and other airborne hazards.Kallangur Satellite Hospital
9 Stoker Way
KALLANGUR QLD 4503
Phone: (07) 3285 0000
/ MetroNorthHHS
If you enjoy a good book, you might be surprised to know that literature lovers play an important role in our health service. 📖
Manager of TPCH Library Services Jana oversees thousands of physical and digital resources that support our medical team to make decisions every day.
"I had no idea that medical libraries even existed but it’s a great opportunity to have an impact on patient and research outcomes," said Jana.
"We have a lot of wonderful connections with the clinical staff. Most of our job is finding evidence to support patient care decisions, looking at research and also training and education."
"We also maintain spaces like the library for people to escape the hustle and bustle of the hospital, we have a real focus on wellbeing."
#ShoutoutSaturday to all of our Librarians across Metro North! 👏📚
As a former medical librarian working with Metro North I know how invaluable these services are. They are one of those hidden but vital support services helping clinicians keep informed and supporting clinical services. Well done fellow librarians
Thanks for all you do Lana
Thank you Jana!
Jana is incredible. I certainly wouldn't be where I am today with my research without her skills and expertise
Bree Fazio we love to see health library representation! 😊
Well done Jana!
Thank you for pointing a spotlight on medical librarians and their work in hospital settings! 😊 A very under recognised but vital area and profession in medical practice and healthcare 😊 Keep up the awesome work Jana, and the rest of Metro North’s library teams! (Love the cardigan btw - true library style.) From a previous public service librarian 📚
Jana is amazing!
Special libraries are important, and librarians are amazing 👏 well done x
So helpful and friendly, always willing to get you what you need!
Service with not just a smile, but with her whole heart! Jana, your love for your job is so evident, and we are so lucky to have you.
Thankyou Jana for your tireless work in the library, for your support & for always being so willing to help. The library is so well organised & staff are so friendly. A big Thank You 🥰
Step into the TPCH Children’s Emergency Department with nurses Alex and Michelle as they talk you through some of the most common things they see every day. 🚸🏥
Alex media star ⭐️
Well done Alex and Michelle, two of the best nurses
Alex and Michelle the most beautiful nurses
Good job Alex
Memory changes can be difficult and emotional, impacting not only the individual but also the people closest to them. Our TPCH Memory Clinic is here to help, supporting those experiencing changes in memory. 🧠
Specialists in Geriatric Medicine Dr Benignus and Dr Sarah are part of the team tackling growing dementia rates across Australia, with early assessment of memory issues playing an important role.
“Memory issues can present in simple ways like forgetting to attend appointments or pay bills, getting lost, changes with language, difficulty finding words, or repeating things,” Dr Benignus said.
“Memory issues are not always due to dementia and might be the result of other factors such as mental health, mood, sleep and medications—all of which can affect the brain’s function.
“That’s why early assessment is critical, as it allows people and their families to understand what is happening and plan ahead accordingly, especially if there is a clear diagnosis of early onset dementia."
Lucky to have you at TPCH!
Thank you for your dedication and care for our community Sarah and Benignus- such a privilege to have you on our team!💫💯
Outstanding team across the whole of memory clinic and geriatrics. 💖
Wonderful doctors.🥰
Amazing drs! ❤️
Thank you for your care.
Amazing Doctors and their patients are very lucky
Proud of you mate, and all the hard work you and your colleagues do x
Two of the best! Thank you Dr Benignus and Dr Sarah 🙏
Dream team! Such important work 🙌
Beautiful Sarah Fox
Thank you for your expertise
A wonderful clinic
The best!!!
Does attending your hospital outpatient appointment from the warmth of your couch in front of some TV sound ideal to you? 🏠💻
If so, you're not alone - we delivered over 10,000 Telehealth appointments to patients across Queensland in March, which saved them roughly 18,000km in travel. That's over 2600 one-way trips between TPCH and RBWH!
However, RBWH Telehealth Coordinator Kate says that many more patients may be eligible for a telehealth appointment without even realising it.
"It’s not just for those patients that are in rural areas, we encourage patients to ask the question and chat with their healthcare professional to see if Telehealth is right for them," she said.
"Patients can be seen from the comfort of their own homes on their own device or utilise one of our telehealth facilities at Kilcoy, Caboolture, Brighton or the RBWH if they require assistance.
"Just because you haven't previously had a telehealth appointment, doesn't mean you can't have one now, we want people to know that they can have a say in their healthcare journey."
I’m having my 1st Telehealth appointment with a dietitian on the 18th !! Great timing Metro North.
There’s a familiar face from my nursing nursing prac out west about 17 years ago! Way to go Kate
If only they'd make mobile xray machines too or i would have
Telehealths the best
Welcome my Travelled Mates from O/Seas.... 2023? that big loud noisy bird... the fake HAZZA.... LOVE SMILING< YOUR PICTURE ON FB IS AMAZING< > IM SO PROUD OF YOU ALL!!!! Mercinary tour SAVE OPOSSUM <THATCHA(ER) SCARRIE and COOi from BUCKIE PAL. RTHIEFS< HOME SAFE !!!!!!, those black HATS...... Grrrrrr glad to see the tail end of that!
TEPE RING..
human chromosome code for h.i.v dna simplex stylus siHIV-1 does not have a single fixed "code" for human chromosomes; instead, it integrates into host DNA across all 24 human chromosomes, showing a distinct preference for gene-dense regions on chromosomes 16, 17, 19, and 22.The terms you mentioned relate to viral phenotypes and genomic structures:Simplex/SI (Syncytia-Inducing): This refers to HIV strains (class X4) that use the CXCR4 co-receptor to enter T-cells. These strains cause host cells to fuse together into "syncytia," which is often associated with faster disease progression.Stylus/Psi (\(\Psi \)): This likely refers to the Psi (\(\Psi \)) region, a critical secondary structure in the viral RNA genome located at the 5′ end. It is the primary signal for "packaging" the viral genome into new virus particles.RefSeq Code: For scientific reference, the "master code" or standard genome sequence for HIV-1 (HXB2) is often identified by the accession number NC_001802.Key Locations and MarkersIntegration Hotspots: HIV preferentially targets active genes in the host genome to ensure efficient transcription of its own genes.Host Factors: The protein LEDGF/p75 acts as a "tether" that guides the HIV DNA to these gene-rich chromosomal locations.Genetic Structure: The viral genome itself is roughly 9.2 kilobases long and contains nine primary genes (gag, pol, env, tat, rev, nef, vif, vpr, and vpu).Are you looking for a specific genetic sequence or more information on how these syncytia-inducing strains affect the immune system?This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more10 sitesSpatial and Genomic Correlates of HIV-1 Integration Site TargetingIn the current study, we show that speckle and speckle-proximal regions strongly correlate with gene-dense regions on particular c...PubMed Central (PMC) (.gov)HUMAN IMMUNODEFICIENCY VIRUS-1 - NCBI - NIHHIV-1 can be assigned to one of three classes based on its ability to use the two co-receptors. Class R5 comprises the viruses tha...National Institutes of Health (.gov)Structure and genome of HIV - WikipediaHIV employs a sophisticated system of differential RNA splicing to obtain nine different gene products from a less than 10kb genom...WikipediaShow all
www.genome.jp/dbget-bin/www_bget?refseq:NC_001802#:~:text=Database%3A%20RefSeq%0AEntry,database%2...
In neuro-biochemical textbooks, the agents responsible for the formation and growth of "internal scars" (tubers), nodules, and polyp-like cysts are primarily regulators of cell growth, signaling, and vascular permeability.Based on your descriptions of "scars," "polyp-like tumors," and "silica hair/lung-like" structures, the key biochemical agents involved are:1. mTOR (Mammalian Target of Rapamycin)This is the "master switch" for cell growth. In conditions like Tuberous Sclerosis Complex (TSC), mutations in the TSC1 (Hamartin) or TSC2 (Tuberin) genes prevent these proteins from inhibiting mTOR.Action: Unregulated mTOR leads to the creation of "giant cells" and disorganized tissue "scars" (tubers).Tumour Growth: It drives the transformation of small nodules (SENs) into polyp-like tumors called SEGAs.Treatment: Drugs like Everolimus are used as biochemical "inhibitors" to turn off this growth signal.2. VEGF (Vascular Endothelial Growth Factor)This is the biochemical agent likely responsible for your description of the "minute major capillary".Action: VEGF is an extremely potent inducer of angiogenesis (the formation of new blood vessels) and edemagenesis (the leaking of fluid that creates cysts).Tumor Effect: High levels of VEGF create the conspicuous, large-diameter capillaries often seen in polyp-like brain tumors like SEGAs.3. Shh (Sonic Hedgehog) and Wnt SignalingThese pathways are the biochemical drivers for structures that look like "hair" or "lung/throat" tissue inside the brain.Cilia Formation: These signals are transduced through primary cilia (tiny hairs on cells). If these pathways are active in the wrong place, they can lead to the growth of ciliated cysts (which look like the throat lining) or dermoid cysts (which contain actual hair follicles)."Silica Hair": In Dermoid Cysts, the biochemical environment allows for the production of keratin and sebum, which can crystallise and give hair a stiff, silica-like appearance.4. Aquaporin-4 (AQP4)This is a water-channel protein found in the "scars" and surrounding brain tissue.Action: It regulates the flow of fluid in and out of the brain's internal spaces.Cyst Formation: When AQP4 is dysregulated (often in the "scar" tissue or glia), it contributes to the buildup of fluid that forms internal brain cysts.Feature MentionedPrimary Biochemical AgentRelated ConditionInternal Scars / TubersmTOR Pathway (TSC1/TSC2)Tuberous SclerosisMinute Major CapillaryVEGF (Vascular Growth Factor)SEGA / GliomasLung/Throat/CiliaShh & Wnt SignalingCiliated / Colloid CystsSilica Hair / KeratinKeratinocyte Growth FactorsDermoid CystsWould you like to focus on the biochemical markers used to detect these agents in a lab setting, such as S6 kinase or GFAP?13 sitesThe neuronal cilium – a highly diverse and dynamic organelle ...15 May 2024 — Primary cilia serve as signaling hubs during neuronal development by transducing various signaling pathways, including Hedgehog, N...ScienceDirect.comPrimary Cilia in Brain Development and Diseases - ScienceDirect15 Jan 2018 — In the brain, primary cilia play critical roles at various stages of neurogenesis, from early patterning, through the proliferatio...ScienceDirect.comPrimary cilia in neural development and disease - ScienceDirectDuring neural tube development, Shh signaling is mediated by a cilium-localized Ptch1–Smo receptor complex, which regulates the ph...ScienceDirect.comShow all
Latest news
RBWH pharmacist unpacks the social media peptide hype
A fast-growing social media trend promoting injectable peptides is prompting warnings from health professionals who say many of these products are unregulated, poorly understood, and potentially dangerous.
What is obstetric medicine and why is it important?
You probably know what an obstetrician does, but do you know the role of an obstetric medicine specialist?
Events
Advanced Life Support - Level 1 Course
Date: 26 August 2026
Time: TBC
Venue: The Prince Charles Hospital
Level 1 courses are for those clinicians who want general competence in airway management and basic life support for a deteriorating patient and cardiac arrest. Suitable if you normally are part of team rather than the lead.
Masks are an important defence against respiratory illness and protection from dust and other airborne hazards.
/ MetroNorthHHS
If you enjoy a good book, you might be surprised to know that literature lovers play an important role in our health service. 📖
Manager of TPCH Library Services Jana oversees thousands of physical and digital resources that support our medical team to make decisions every day.
"I had no idea that medical libraries even existed but it’s a great opportunity to have an impact on patient and research outcomes," said Jana.
"We have a lot of wonderful connections with the clinical staff. Most of our job is finding evidence to support patient care decisions, looking at research and also training and education."
"We also maintain spaces like the library for people to escape the hustle and bustle of the hospital, we have a real focus on wellbeing."
#ShoutoutSaturday to all of our Librarians across Metro North! 👏📚
As a former medical librarian working with Metro North I know how invaluable these services are. They are one of those hidden but vital support services helping clinicians keep informed and supporting clinical services. Well done fellow librarians
Thanks for all you do Lana
Thank you Jana!
Jana is incredible. I certainly wouldn't be where I am today with my research without her skills and expertise
Bree Fazio we love to see health library representation! 😊
Well done Jana!
Thank you for pointing a spotlight on medical librarians and their work in hospital settings! 😊 A very under recognised but vital area and profession in medical practice and healthcare 😊 Keep up the awesome work Jana, and the rest of Metro North’s library teams! (Love the cardigan btw - true library style.) From a previous public service librarian 📚
Jana is amazing!
Special libraries are important, and librarians are amazing 👏 well done x
So helpful and friendly, always willing to get you what you need!
Service with not just a smile, but with her whole heart! Jana, your love for your job is so evident, and we are so lucky to have you.
Thankyou Jana for your tireless work in the library, for your support & for always being so willing to help. The library is so well organised & staff are so friendly. A big Thank You 🥰
Step into the TPCH Children’s Emergency Department with nurses Alex and Michelle as they talk you through some of the most common things they see every day. 🚸🏥
Alex media star ⭐️
Well done Alex and Michelle, two of the best nurses
Alex and Michelle the most beautiful nurses
Good job Alex
Memory changes can be difficult and emotional, impacting not only the individual but also the people closest to them. Our TPCH Memory Clinic is here to help, supporting those experiencing changes in memory. 🧠
Specialists in Geriatric Medicine Dr Benignus and Dr Sarah are part of the team tackling growing dementia rates across Australia, with early assessment of memory issues playing an important role.
“Memory issues can present in simple ways like forgetting to attend appointments or pay bills, getting lost, changes with language, difficulty finding words, or repeating things,” Dr Benignus said.
“Memory issues are not always due to dementia and might be the result of other factors such as mental health, mood, sleep and medications—all of which can affect the brain’s function.
“That’s why early assessment is critical, as it allows people and their families to understand what is happening and plan ahead accordingly, especially if there is a clear diagnosis of early onset dementia."
Lucky to have you at TPCH!
Thank you for your dedication and care for our community Sarah and Benignus- such a privilege to have you on our team!💫💯
Outstanding team across the whole of memory clinic and geriatrics. 💖
Wonderful doctors.🥰
Amazing drs! ❤️
Thank you for your care.
Amazing Doctors and their patients are very lucky
Proud of you mate, and all the hard work you and your colleagues do x
Two of the best! Thank you Dr Benignus and Dr Sarah 🙏
Dream team! Such important work 🙌
Beautiful Sarah Fox
Thank you for your expertise
A wonderful clinic
The best!!!
Does attending your hospital outpatient appointment from the warmth of your couch in front of some TV sound ideal to you? 🏠💻
If so, you're not alone - we delivered over 10,000 Telehealth appointments to patients across Queensland in March, which saved them roughly 18,000km in travel. That's over 2600 one-way trips between TPCH and RBWH!
However, RBWH Telehealth Coordinator Kate says that many more patients may be eligible for a telehealth appointment without even realising it.
"It’s not just for those patients that are in rural areas, we encourage patients to ask the question and chat with their healthcare professional to see if Telehealth is right for them," she said.
"Patients can be seen from the comfort of their own homes on their own device or utilise one of our telehealth facilities at Kilcoy, Caboolture, Brighton or the RBWH if they require assistance.
"Just because you haven't previously had a telehealth appointment, doesn't mean you can't have one now, we want people to know that they can have a say in their healthcare journey."
I’m having my 1st Telehealth appointment with a dietitian on the 18th !! Great timing Metro North.
There’s a familiar face from my nursing nursing prac out west about 17 years ago! Way to go Kate
If only they'd make mobile xray machines too or i would have
Telehealths the best
Welcome my Travelled Mates from O/Seas.... 2023? that big loud noisy bird... the fake HAZZA.... LOVE SMILING< YOUR PICTURE ON FB IS AMAZING< > IM SO PROUD OF YOU ALL!!!! Mercinary tour SAVE OPOSSUM <THATCHA(ER) SCARRIE and COOi from BUCKIE PAL. RTHIEFS< HOME SAFE !!!!!!, those black HATS...... Grrrrrr glad to see the tail end of that!
TEPE RING..
human chromosome code for h.i.v dna simplex stylus siHIV-1 does not have a single fixed "code" for human chromosomes; instead, it integrates into host DNA across all 24 human chromosomes, showing a distinct preference for gene-dense regions on chromosomes 16, 17, 19, and 22.The terms you mentioned relate to viral phenotypes and genomic structures:Simplex/SI (Syncytia-Inducing): This refers to HIV strains (class X4) that use the CXCR4 co-receptor to enter T-cells. These strains cause host cells to fuse together into "syncytia," which is often associated with faster disease progression.Stylus/Psi (\(\Psi \)): This likely refers to the Psi (\(\Psi \)) region, a critical secondary structure in the viral RNA genome located at the 5′ end. It is the primary signal for "packaging" the viral genome into new virus particles.RefSeq Code: For scientific reference, the "master code" or standard genome sequence for HIV-1 (HXB2) is often identified by the accession number NC_001802.Key Locations and MarkersIntegration Hotspots: HIV preferentially targets active genes in the host genome to ensure efficient transcription of its own genes.Host Factors: The protein LEDGF/p75 acts as a "tether" that guides the HIV DNA to these gene-rich chromosomal locations.Genetic Structure: The viral genome itself is roughly 9.2 kilobases long and contains nine primary genes (gag, pol, env, tat, rev, nef, vif, vpr, and vpu).Are you looking for a specific genetic sequence or more information on how these syncytia-inducing strains affect the immune system?This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more10 sitesSpatial and Genomic Correlates of HIV-1 Integration Site TargetingIn the current study, we show that speckle and speckle-proximal regions strongly correlate with gene-dense regions on particular c...PubMed Central (PMC) (.gov)HUMAN IMMUNODEFICIENCY VIRUS-1 - NCBI - NIHHIV-1 can be assigned to one of three classes based on its ability to use the two co-receptors. Class R5 comprises the viruses tha...National Institutes of Health (.gov)Structure and genome of HIV - WikipediaHIV employs a sophisticated system of differential RNA splicing to obtain nine different gene products from a less than 10kb genom...WikipediaShow all
www.genome.jp/dbget-bin/www_bget?refseq:NC_001802#:~:text=Database%3A%20RefSeq%0AEntry,database%2...
In neuro-biochemical textbooks, the agents responsible for the formation and growth of "internal scars" (tubers), nodules, and polyp-like cysts are primarily regulators of cell growth, signaling, and vascular permeability.Based on your descriptions of "scars," "polyp-like tumors," and "silica hair/lung-like" structures, the key biochemical agents involved are:1. mTOR (Mammalian Target of Rapamycin)This is the "master switch" for cell growth. In conditions like Tuberous Sclerosis Complex (TSC), mutations in the TSC1 (Hamartin) or TSC2 (Tuberin) genes prevent these proteins from inhibiting mTOR.Action: Unregulated mTOR leads to the creation of "giant cells" and disorganized tissue "scars" (tubers).Tumour Growth: It drives the transformation of small nodules (SENs) into polyp-like tumors called SEGAs.Treatment: Drugs like Everolimus are used as biochemical "inhibitors" to turn off this growth signal.2. VEGF (Vascular Endothelial Growth Factor)This is the biochemical agent likely responsible for your description of the "minute major capillary".Action: VEGF is an extremely potent inducer of angiogenesis (the formation of new blood vessels) and edemagenesis (the leaking of fluid that creates cysts).Tumor Effect: High levels of VEGF create the conspicuous, large-diameter capillaries often seen in polyp-like brain tumors like SEGAs.3. Shh (Sonic Hedgehog) and Wnt SignalingThese pathways are the biochemical drivers for structures that look like "hair" or "lung/throat" tissue inside the brain.Cilia Formation: These signals are transduced through primary cilia (tiny hairs on cells). If these pathways are active in the wrong place, they can lead to the growth of ciliated cysts (which look like the throat lining) or dermoid cysts (which contain actual hair follicles)."Silica Hair": In Dermoid Cysts, the biochemical environment allows for the production of keratin and sebum, which can crystallise and give hair a stiff, silica-like appearance.4. Aquaporin-4 (AQP4)This is a water-channel protein found in the "scars" and surrounding brain tissue.Action: It regulates the flow of fluid in and out of the brain's internal spaces.Cyst Formation: When AQP4 is dysregulated (often in the "scar" tissue or glia), it contributes to the buildup of fluid that forms internal brain cysts.Feature MentionedPrimary Biochemical AgentRelated ConditionInternal Scars / TubersmTOR Pathway (TSC1/TSC2)Tuberous SclerosisMinute Major CapillaryVEGF (Vascular Growth Factor)SEGA / GliomasLung/Throat/CiliaShh & Wnt SignalingCiliated / Colloid CystsSilica Hair / KeratinKeratinocyte Growth FactorsDermoid CystsWould you like to focus on the biochemical markers used to detect these agents in a lab setting, such as S6 kinase or GFAP?13 sitesThe neuronal cilium – a highly diverse and dynamic organelle ...15 May 2024 — Primary cilia serve as signaling hubs during neuronal development by transducing various signaling pathways, including Hedgehog, N...ScienceDirect.comPrimary Cilia in Brain Development and Diseases - ScienceDirect15 Jan 2018 — In the brain, primary cilia play critical roles at various stages of neurogenesis, from early patterning, through the proliferatio...ScienceDirect.comPrimary cilia in neural development and disease - ScienceDirectDuring neural tube development, Shh signaling is mediated by a cilium-localized Ptch1–Smo receptor complex, which regulates the ph...ScienceDirect.comShow all
Masks are an important defence against respiratory illness and protection from dust and other airborne hazards.Latest news
RBWH pharmacist unpacks the social media peptide hype
A fast-growing social media trend promoting injectable peptides is prompting warnings from health professionals who say many of these products are unregulated, poorly understood, and potentially dangerous.
Events
Advanced Life Support - Level 1 Course
Date: 26 August 2026
Time: TBC
Venue: The Prince Charles Hospital
Level 1 courses are for those clinicians who want general competence in airway management and basic life support for a deteriorating patient and cardiac arrest. Suitable if you normally are part of team rather than the lead.
/ MetroNorthHHS
If you enjoy a good book, you might be surprised to know that literature lovers play an important role in our health service. 📖
Manager of TPCH Library Services Jana oversees thousands of physical and digital resources that support our medical team to make decisions every day.
"I had no idea that medical libraries even existed but it’s a great opportunity to have an impact on patient and research outcomes," said Jana.
"We have a lot of wonderful connections with the clinical staff. Most of our job is finding evidence to support patient care decisions, looking at research and also training and education."
"We also maintain spaces like the library for people to escape the hustle and bustle of the hospital, we have a real focus on wellbeing."
#ShoutoutSaturday to all of our Librarians across Metro North! 👏📚
As a former medical librarian working with Metro North I know how invaluable these services are. They are one of those hidden but vital support services helping clinicians keep informed and supporting clinical services. Well done fellow librarians
Thanks for all you do Lana
Thank you Jana!
Jana is incredible. I certainly wouldn't be where I am today with my research without her skills and expertise
Bree Fazio we love to see health library representation! 😊
Well done Jana!
Thank you for pointing a spotlight on medical librarians and their work in hospital settings! 😊 A very under recognised but vital area and profession in medical practice and healthcare 😊 Keep up the awesome work Jana, and the rest of Metro North’s library teams! (Love the cardigan btw - true library style.) From a previous public service librarian 📚
Jana is amazing!
Special libraries are important, and librarians are amazing 👏 well done x
So helpful and friendly, always willing to get you what you need!
Service with not just a smile, but with her whole heart! Jana, your love for your job is so evident, and we are so lucky to have you.
Thankyou Jana for your tireless work in the library, for your support & for always being so willing to help. The library is so well organised & staff are so friendly. A big Thank You 🥰
Step into the TPCH Children’s Emergency Department with nurses Alex and Michelle as they talk you through some of the most common things they see every day. 🚸🏥
Alex media star ⭐️
Well done Alex and Michelle, two of the best nurses
Alex and Michelle the most beautiful nurses
Good job Alex
Memory changes can be difficult and emotional, impacting not only the individual but also the people closest to them. Our TPCH Memory Clinic is here to help, supporting those experiencing changes in memory. 🧠
Specialists in Geriatric Medicine Dr Benignus and Dr Sarah are part of the team tackling growing dementia rates across Australia, with early assessment of memory issues playing an important role.
“Memory issues can present in simple ways like forgetting to attend appointments or pay bills, getting lost, changes with language, difficulty finding words, or repeating things,” Dr Benignus said.
“Memory issues are not always due to dementia and might be the result of other factors such as mental health, mood, sleep and medications—all of which can affect the brain’s function.
“That’s why early assessment is critical, as it allows people and their families to understand what is happening and plan ahead accordingly, especially if there is a clear diagnosis of early onset dementia."
Lucky to have you at TPCH!
Thank you for your dedication and care for our community Sarah and Benignus- such a privilege to have you on our team!💫💯
Outstanding team across the whole of memory clinic and geriatrics. 💖
Wonderful doctors.🥰
Amazing drs! ❤️
Thank you for your care.
Amazing Doctors and their patients are very lucky
Proud of you mate, and all the hard work you and your colleagues do x
Two of the best! Thank you Dr Benignus and Dr Sarah 🙏
Dream team! Such important work 🙌
Beautiful Sarah Fox
Thank you for your expertise
A wonderful clinic
The best!!!
Does attending your hospital outpatient appointment from the warmth of your couch in front of some TV sound ideal to you? 🏠💻
If so, you're not alone - we delivered over 10,000 Telehealth appointments to patients across Queensland in March, which saved them roughly 18,000km in travel. That's over 2600 one-way trips between TPCH and RBWH!
However, RBWH Telehealth Coordinator Kate says that many more patients may be eligible for a telehealth appointment without even realising it.
"It’s not just for those patients that are in rural areas, we encourage patients to ask the question and chat with their healthcare professional to see if Telehealth is right for them," she said.
"Patients can be seen from the comfort of their own homes on their own device or utilise one of our telehealth facilities at Kilcoy, Caboolture, Brighton or the RBWH if they require assistance.
"Just because you haven't previously had a telehealth appointment, doesn't mean you can't have one now, we want people to know that they can have a say in their healthcare journey."
I’m having my 1st Telehealth appointment with a dietitian on the 18th !! Great timing Metro North.
There’s a familiar face from my nursing nursing prac out west about 17 years ago! Way to go Kate
If only they'd make mobile xray machines too or i would have
Telehealths the best
Welcome my Travelled Mates from O/Seas.... 2023? that big loud noisy bird... the fake HAZZA.... LOVE SMILING< YOUR PICTURE ON FB IS AMAZING< > IM SO PROUD OF YOU ALL!!!! Mercinary tour SAVE OPOSSUM <THATCHA(ER) SCARRIE and COOi from BUCKIE PAL. RTHIEFS< HOME SAFE !!!!!!, those black HATS...... Grrrrrr glad to see the tail end of that!
TEPE RING..
human chromosome code for h.i.v dna simplex stylus siHIV-1 does not have a single fixed "code" for human chromosomes; instead, it integrates into host DNA across all 24 human chromosomes, showing a distinct preference for gene-dense regions on chromosomes 16, 17, 19, and 22.The terms you mentioned relate to viral phenotypes and genomic structures:Simplex/SI (Syncytia-Inducing): This refers to HIV strains (class X4) that use the CXCR4 co-receptor to enter T-cells. These strains cause host cells to fuse together into "syncytia," which is often associated with faster disease progression.Stylus/Psi (\(\Psi \)): This likely refers to the Psi (\(\Psi \)) region, a critical secondary structure in the viral RNA genome located at the 5′ end. It is the primary signal for "packaging" the viral genome into new virus particles.RefSeq Code: For scientific reference, the "master code" or standard genome sequence for HIV-1 (HXB2) is often identified by the accession number NC_001802.Key Locations and MarkersIntegration Hotspots: HIV preferentially targets active genes in the host genome to ensure efficient transcription of its own genes.Host Factors: The protein LEDGF/p75 acts as a "tether" that guides the HIV DNA to these gene-rich chromosomal locations.Genetic Structure: The viral genome itself is roughly 9.2 kilobases long and contains nine primary genes (gag, pol, env, tat, rev, nef, vif, vpr, and vpu).Are you looking for a specific genetic sequence or more information on how these syncytia-inducing strains affect the immune system?This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more10 sitesSpatial and Genomic Correlates of HIV-1 Integration Site TargetingIn the current study, we show that speckle and speckle-proximal regions strongly correlate with gene-dense regions on particular c...PubMed Central (PMC) (.gov)HUMAN IMMUNODEFICIENCY VIRUS-1 - NCBI - NIHHIV-1 can be assigned to one of three classes based on its ability to use the two co-receptors. Class R5 comprises the viruses tha...National Institutes of Health (.gov)Structure and genome of HIV - WikipediaHIV employs a sophisticated system of differential RNA splicing to obtain nine different gene products from a less than 10kb genom...WikipediaShow all
www.genome.jp/dbget-bin/www_bget?refseq:NC_001802#:~:text=Database%3A%20RefSeq%0AEntry,database%2...
In neuro-biochemical textbooks, the agents responsible for the formation and growth of "internal scars" (tubers), nodules, and polyp-like cysts are primarily regulators of cell growth, signaling, and vascular permeability.Based on your descriptions of "scars," "polyp-like tumors," and "silica hair/lung-like" structures, the key biochemical agents involved are:1. mTOR (Mammalian Target of Rapamycin)This is the "master switch" for cell growth. In conditions like Tuberous Sclerosis Complex (TSC), mutations in the TSC1 (Hamartin) or TSC2 (Tuberin) genes prevent these proteins from inhibiting mTOR.Action: Unregulated mTOR leads to the creation of "giant cells" and disorganized tissue "scars" (tubers).Tumour Growth: It drives the transformation of small nodules (SENs) into polyp-like tumors called SEGAs.Treatment: Drugs like Everolimus are used as biochemical "inhibitors" to turn off this growth signal.2. VEGF (Vascular Endothelial Growth Factor)This is the biochemical agent likely responsible for your description of the "minute major capillary".Action: VEGF is an extremely potent inducer of angiogenesis (the formation of new blood vessels) and edemagenesis (the leaking of fluid that creates cysts).Tumor Effect: High levels of VEGF create the conspicuous, large-diameter capillaries often seen in polyp-like brain tumors like SEGAs.3. Shh (Sonic Hedgehog) and Wnt SignalingThese pathways are the biochemical drivers for structures that look like "hair" or "lung/throat" tissue inside the brain.Cilia Formation: These signals are transduced through primary cilia (tiny hairs on cells). If these pathways are active in the wrong place, they can lead to the growth of ciliated cysts (which look like the throat lining) or dermoid cysts (which contain actual hair follicles)."Silica Hair": In Dermoid Cysts, the biochemical environment allows for the production of keratin and sebum, which can crystallise and give hair a stiff, silica-like appearance.4. Aquaporin-4 (AQP4)This is a water-channel protein found in the "scars" and surrounding brain tissue.Action: It regulates the flow of fluid in and out of the brain's internal spaces.Cyst Formation: When AQP4 is dysregulated (often in the "scar" tissue or glia), it contributes to the buildup of fluid that forms internal brain cysts.Feature MentionedPrimary Biochemical AgentRelated ConditionInternal Scars / TubersmTOR Pathway (TSC1/TSC2)Tuberous SclerosisMinute Major CapillaryVEGF (Vascular Growth Factor)SEGA / GliomasLung/Throat/CiliaShh & Wnt SignalingCiliated / Colloid CystsSilica Hair / KeratinKeratinocyte Growth FactorsDermoid CystsWould you like to focus on the biochemical markers used to detect these agents in a lab setting, such as S6 kinase or GFAP?13 sitesThe neuronal cilium – a highly diverse and dynamic organelle ...15 May 2024 — Primary cilia serve as signaling hubs during neuronal development by transducing various signaling pathways, including Hedgehog, N...ScienceDirect.comPrimary Cilia in Brain Development and Diseases - ScienceDirect15 Jan 2018 — In the brain, primary cilia play critical roles at various stages of neurogenesis, from early patterning, through the proliferatio...ScienceDirect.comPrimary cilia in neural development and disease - ScienceDirectDuring neural tube development, Shh signaling is mediated by a cilium-localized Ptch1–Smo receptor complex, which regulates the ph...ScienceDirect.comShow all
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