Journal articles

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CONCLUSIONS: STPA was effectively used to assess the Radixact Synchrony system's real-time adaptive radiation therapy capabilities, providing insight into how the system could become unsafe throughout the patient journey. While focused on Radixact Synchrony and real-time adaptive radiation therapy, this study offers a transferable example of STPA application, from analysis initialization to mitigation, that can […]

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BACKGROUND: In focal segmental glomerulosclerosis (FSGS), transient receptor potential cation channel, subfamily C, member 6 (TRPC6) overactivity might cause podocyte loss and progressive kidney function decline. This exploratory study assessed the safety and efficacy of a novel once-daily oral selective TRPC6 inhibitor, BI 764198.

CONCLUSIONS: The V˙O(2)RR is an easily calculated parameter from a CPET that predicts outcomes in HF. Additionally, when combined with V˙O(2peak), the V˙O(2)RR offers greater prognostic value in predicting outcomes in HF populations.

CONCLUSION: Incidence of EGCT in Australia is consistent with published literature. Treatment patterns reflect international practices. Primary mediastinal non-seminoma has the poorest outcomes. Primary retroperitoneal and primary mediastinal seminomas have excellent outcomes.

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is characterized by the triad of hypoparathyroidism, Addison's disease, and chronic mucocutaneous candidiasis due to biallelic deleterious variants in AIRE. However, emerging evidence has established that some monoallelic variants affecting specific functional domains may also drive autoimmunity by negative dominance. Here, we describe a novel heterozygous AIRE variant, c.1010G>T (p.Cys337Phe), in […]

We developed Standardised Minimum 3D Distance (SM3DD), an entirely cell segmentation/annotation-free approach to the analysis of spatial RNA datasets, using it to compare lung tissue from 16 clinically normal individuals to that of 18 SARS-CoV-2 patients who died from acute respiratory distress syndrome. RNA spatial coordinates were determined using the CosMx™ Spatial Molecular Imager (Bruker […]

CONCLUSION: Commonly used methods to determine clinical relevance are conceptually and methodologically limited to interpret between-group differences in trials of patients with OA. To advance the field, we propose greater development and consideration of the SWE, given its conceptual advantages. While promising, the SWE is a multi-domain construct that can be challenging to apply and […]

CONCLUSION: The current literature highlights the developmental risk in FGR vs. AGA infants. FGR neonates have significantly different MRI results compared to AGA neonates and MRI findings in the neonate are associated with adverse neurodevelopmental outcomes. However, current evidence is insufficient to firmly establish MRI prognostic capabilities specifically for FGR infants. Sub-group analysis of the […]

CONCLUSION: HRT-associated melasma is underrepresented in the literature. Clinicians should counsel at-risk women on melasma risk and ensure strict photoprotection. Prospective studies are needed to clarify melasma risk across different HRT formulations.

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CONCLUSION: Midwife-led continuity of care was not associated with a statistically significant difference in breastfeeding rates up to four months postnatal. Further investigation to better understand how midwives can support women to improve breastfeeding outcomes is required.

Fetal growth restriction (FGR) refers to a fetus that does not reach expected full growth, secondary to placental dysfunction and reduced oxygen and nutrient availability. FGR is associated with mortality or morbidity, including suboptimal brain development. Infants with FGR have reduced brain volume and diffuse, multicellular neuropathology that mediates neurological dysfunctions. In utero, reduced fetal […]

CONCLUSIONS: Patients denying supine sleep in the laboratory were more likely to misperceive sleep position on PSG, with younger females under-reporting supine sleep. Understanding contributors to misperception may influence decisions regarding supine sleep sampling in the laboratory, as well clinical decision making.