Journal articles

Australia's National Lung Cancer Screening Program will commence in July 2025, targeted at individuals aged 50-70 years with a 30 pack-year smoking history (equivalent to 20 cigarettes per day for 30 years), who either currently smoke or have quit within the past 10 years. We forecasted the number of screening-eligible individuals over the first 5 […]

CONCLUSION: Vestibulo-ocular dysfunction is common in male adolescent rugby union players and positive findings should include comparison with baseline function or symptom profile. The wider impact of vestibulo-ocular dysfunction on sporting performance in adolescents is unknown.

Effective sepsis treatment requires not only the timely administration of appropriate antimicrobials but also precise dosing to maximize patient survival in intensive care units (ICUs). However, the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in critically ill patients differ significantly from those in the general population. Understanding these pathophysiological changes is essential for optimizing antibiotic […]

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People with cognitive impairment account for ~30% of hospital admissions, commonly require invasive procedures, and are vulnerable to hospital-acquired complications. This sequential mixed methods research explored clinician approaches to procedures for patients experiencing cognitive impairment. Data were collected 2021-2022 in a 26-bed medical ward containing a secure eight-bed unit in Australia. Observational data and semi-structured […]

CONCLUSIONS: This is the first study to investigate the effects of genetic variants on the ECS gene transcription and indicates genetic variants have significant influence that are unique to each tissue. Our results highlight the effect of individual variation and the impact endocannabinoid based therapies may have on different tissue and physiological systems.

Background: Central venous catheterization (CVC) is a frequently performed procedure in anesthesia and critical care settings. Modern procedures have improved significantly, particularly with increasingly sophisticated venous verification methods and ultrasound guidance. While the associated historical complication rates reflect this improvement, complications such as inadvertent arterial puncture, arterial cannulation, pneumothorax, deep vein thrombosis, and catheter-associated infection […]

Veno-arterial extracorporeal membrane oxygenation (VA ECMO) for the management of refractory cardiogenic shock (CS) has been widely used in recent years. Increased left ventricular (LV) afterload induced by retrograde flow remains a limiting factor, which is particularly evident during peripheral VA ECMO support. The concomitant use of the intra-aortic balloon pump (IABP) is an established […]

Electronic cigarette (EC) use, especially among younger members of society, has grown to concerning levels in many countries, including Australia and New Zealand. Uptake in the general population, driven by technological and pharmacological innovations, and accelerated by aggressive tobacco/vaping industry marketing, has outpaced medical research. As the harms of EC use become increasingly evident, the […]

CONCLUSIONS: This study revealed significant variation in OPAT practice. Further study is needed to understand the reasons for these differences and whether better alignment of practice could improve patient outcomes, antimicrobial stewardship practice and resource utilization.

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CONCLUSIONS: Patients receiving procedural sedation for endoscopic procedures may experience heat loss comparable to the initial phase of general or neuraxial anesthesia. Active warming and continuous temperature monitoring are yet to be implemented in this population.

CONCLUSIONS: The use of the PTSD Checklist for DSM-5 administered by neonatal nurses can help identify potential signs of parental stress or trauma. Further research must assess whether early screening and referral improve parental outcomes.

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The UK Biobank (UKB) is a population-based resource of genetic, health, lifestyle, sociodemographic, and linked clinical data for ~500,000 volunteers. Previous analyses of health determinants have shown that the UKB is not representative of the population from which it is drawn. However, representativeness from a general health-outcomes perspective is unknown, but could be assessed using […]