Journal articles

CONCLUSION: In this cohort, there was no evidence of an association between objectively measured supine sleep and customised birthweight centile. Yet to be identified mechanisms unrelated to fetal growth may be responsible for supine going-to-sleep position being a risk factor for late stillbirth. Further prospective investigation is needed to untangle cause and effect; however, given […]

A subgroup analysis of efficacy, safety and QOL in patients who received selinexor in combination with bortezomib and dexamethasone (SVd) with and without selinexor dose reduction and who had lenalidomide-refractory disease in the phase 3 BOSTON trial showed improvements in efficacy, quality of life (QOL) and safety outcomes with selinexor dose reduction in this difficult-to-treat […]

In this case report, the authors describe the use of venoarteriovenous extracorporeal life support (V-AV ECLS) for a patient presenting with severe takotsubo cardiomyopathy (TCM) secondary to a breakthrough seizure. Given a presentation of hypoxia, V-AV ECLS was instituted and weaned quickly after cardiac recovery. The patient was discharged home after complications from cardiogenic shock […]

Erysipelothrix rhusiopathiae is a zoonotic, gram-positive bacillus that is a virulent cause of infective endocarditis (IE) and incurs a high mortality rate. Its virulence is compounded by intrinsic resistance to common empirical agents including vancomycin and aminoglycosides. Given it is historically associated with a high rate of bacteraemia, its presentation in this case report as […]

CONCLUSIONS: Combination treatment with a β-lactam was associated with a duration-dependent effect on clearance of bacteremia and AKI. Short-duration antistaphylococcal β-lactam during the empiric treatment period was associated with faster clearance of MRSA bacteremia, and may not substantially increase the risk of nephrotoxicity.

CONCLUSIONS: Challenging history taking encounters are common. Little is known of the relative importance of factors associated with challenging history taking encounters or the impact of suggested strategies. Many of the suggested strategies to facilitate meaningful communication in these situations involve a departure from standard history taking. More research is required to better define the […]

Impairments in speech production occur at a high rate after surgical resection of primary brain tumours. Due to their spatial heterogeneity, tumours can be problematic for voxel-wise lesion-symptom mapping. In addition, lesion maps of resection cavities may not capture displaced/deformed tracts, limiting the accuracy of white matter disconnection approaches based on population average atlas templates. […]

CONCLUSION: Harnessing IQNs' specialised skills is not only a workforce imperative but a matter of justice. Balancing regulatory standards for patient safety with equitable recognition practices will enable nurses to act as agents of transformative change.

Lung cancer is the most frequent cause of cancer-related mortality globally. In recent years, the treatment landscape for advanced-stage non-small-cell lung cancer (NSCLC) has been transformed by the advent of immunotherapy, which has yielded unprecedented and durable clinical responses for some patients. This shift has powered a significant expansion of novel immunotherapeutic strategies in oncology […]

CONCLUSIONS: The 2022 census highlights a workforce under strain from high clinical demand, limited growth, and looming retirements. Key challenges include inequitable representation of Māori and Pasifika clinicians, declining subspecialty capacity, and risks of burnout. Coordinated national workforce planning, with a focus on recruitment, retention, equity, and flexible models of training and employment, will be […]

Current medical education is caught in a paradox: it aims to train compassionate patient advocates yet its structure often fosters compliance and burnout, ill-equipping physicians to challenge the systemic drivers of poor health. The rapid integration of artificial intelligence (AI) into clinical practice is automating the cognitive-diagnostic tasks that have long defined physician training, from […]

CONCLUSION: Understanding which tools are validated and fit-for-purpose is essential for researchers, educators and health services seeking to measure and improve digital health competence among healthcare professionals. There is a need to expand research into interprofessional measures of healthcare workforce digital competence to support effective workforce transformation.

CONCLUSION: This study highlights variability in managing paediatric fractures despite established standards. In line with recommendations, a high proportion of reductions are now being performed in EDs. Particular areas requiring improvement are the management of paediatric pain, documented assessment of neurovascular status, and the provision of patient information. We recommend that hospitals review their current […]

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CONCLUSION: Our results support the feasibility of neoadjuvant systemic therapy in resectable NSCLC and explore the novel combination of nivolumab with denosumab. CD8 T-cell infiltration correlates with pathological response, warranting ongoing translational research to better understand patient selection for such novel combinations.