Journal articles

This viewpoint reports on the outcomes of the 2023 Australian interest holder meeting on the use of patient-reported outcomes (PROs) in cancer care and discusses its findings in the context of the significant national investment into the collection of PRO data in Australia. The interest holders emphasised the importance for PRO data collection to be […]

CONCLUSION: Predischarge factors, such as age, sex, preexisting conditions, and injury severity, are significant predictors of poor long-term HRQOL. Knowledge of these predischarge factors is important to improve long-term outcomes. Additional research should include hospital treatment and diagnostic factors.

Prostate biopsy prior to radical treatment for prostate cancer is a common practice worldwide to allow diagnosis, prognostication, and treatment planning. However, recent advances in prostate multiparametric magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen (PSMA)-positron emission tomography (PET) have made the possibility of a "biopsy-free" radical prostatectomy, without prior biopsy, closer to reality than […]

No abstract

CONCLUSION: This web-based nomogram will facilitate the discussion of whether individual patients with malignant colorectal polyps can be safely managed with polypectomy or whether the patient should undergo colorectal resection. This nomogram is now available at https://malignantpolyp.com/risk-calculator.

ObjectivePeople with schizophrenia are at increased risk of metabolic syndrome (MetS), contributing to excess morbidity and mortality. This study examined MetS monitoring rates and prevalence in people with schizophrenia receiving public mental health care in Queensland.MethodsData from the Consumer Integrated Mental Health and Addiction Application (CIMHA) were extracted for individuals aged 18-64 with a schizophrenia […]

CONCLUSION: Pulsatile flow ECMO with better placement of ECMO pulse delivery in the cardiac cycle could develop greater pulsatility into the aorta, which is crucial for transferring haemodynamic energy and reducing cardiac afterload.

BACKGROUND: Ataxia-telangiectasia (A-T) is a rare multisystem disease characterised by neurodegenerative cerebellar ataxia, lung disease, immune deficiency, high cancer risk, and mitochondrial dysfunction. A-T cells demonstrate defective endoplasmic reticulum-mitochondrial connectivity disrupting calcium homoeostasis and mitochondrial fusion, which are corrected in vitro by the triheptanoin metabolite, heptanoate.

Echocardiographic assessment of left ventricular (LV) diastolic function is an integral part of the routine evaluation of patients presenting with symptoms of dyspnea or clinical concerns for heart failure. Given the presence of diastolic dysfunction in many cardiovascular diseases, clinical reports should include comments on diastolic function and/or left atrial (LA) pressure whenever possible. Since […]

Herein, we explore the potential influence of Schistosoma mansoni Sambon, 1907 soluble egg antigen (SmSEA) on the immunopathology of COVID-19 in K18-hACE2 mice infected with an Omicron BA.5 isolate of SARS-CoV-2. SmSEA treatment was delivered in a single dose by intraperitoneal injection, shortly after intrapulmonary inoculation of SARS-CoV-2. RNA-seq identified 36 differentially expressed genes in […]

CONCLUSIONS: Both studies met their primary endpoint. The safety profiles of nivolumab + ipilimumab as FRC or ASI were acceptable and manageable.

BACKGROUND: Population ageing and rising levels of non-communicable diseases are increasing the number of people living with and dying from advanced serious illnesses globally. Many of these people are hospitalised more than once in their last year of life. While there is sound evidence on what patients and their families require for safe and high-quality […]

CONCLUSION: PaNURAMA demonstrates strong validity and reliability in risk stratification and escort allocation supporting its use in transfer decision making for non-critical paediatric IHTs.

CONCLUSION: Improved understanding of the sonographic anatomy, technique and normal imaging appearances of ulnar-sided wrist structures can enhance the quality of imaging and subsequently the diagnosis of structural causes of pain, which can guide patient management.

Background: Motor neuron disease (MND) profoundly impacts mobility, yet gait-specific dysfunctions due to MND remain poorly understood. Methods: We characterized lower-limb gait alterations in people living with MND (plwMND) using advanced biomechanical tools. Nine plwMND and nine non-neurodegenerative disease controls walked on an instrumented treadmill at self-selected speeds. Ground reaction forces and joint motions were […]