Journal articles

Chimeric antigen receptor T-cell (CAR T) therapy is an innovative form of cancer treatment, wherein a patient's own T cells are genetically modified to incorporate chimeric antigen receptors (CARs), enabling them to selectively identify and destroy cancer cells. This personalised T cell-based immunotherapy has shown promising results in treating hematological malignancies, such as certain types […]

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CONCLUSIONS: Pulmonary complications increased after urgent compared with elective cardiac surgical procedures, with a higher incidence of pneumonia, respiratory failure, pleural effusion, and pulmonary embolism.

CONCLUSION: Pharmacists used established criteria from clinical resources to identify high-risk patients for referral; however, they also relied on clinical judgement. Referrals aimed to prevent medication related harm and improve communication with patients and healthcare providers. Future research should evaluate the effectiveness of clinical judgement to ensure high-risk patients are identified for transition of care […]

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CONCLUSION: In patients undergoing MCS device implantation, intravenous fluconazole 200 mg administered pre-operatively and continued daily for 5 days is insufficient for Candida spp. with MICs > 1 mg/L (prophylaxis, AUC(0-24)/MIC ≥ 50) and > 0.5 mg/L (treatment, AUC(0-24)/MIC ≥ 100).

CONCLUSION: Vitamin D supplementation did not prevent PC progression, although reduced prevalence of CBMN markers may indicate a benefit of vitamin D supplementation.

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AmpC β-lactamases, found in certain Enterobacterales, confer resistance to third-generation cephalosporins, some β-lactam/β-lactamase inhibitor combinations, and cephamycins. They may be chromosomal or plasmid-mediated. Generally, third-generation cephalosporins are avoided in the treatment of high-risk AmpC producers, with cefepime or carbapenems being preferred for severe infections. Non-β-lactam options (fluoroquinolones, trimethoprim-sulfamethoxazole, and aminoglycosides) remain viable...

Novel technologies for the diagnosis of bloodstream infection are emerging, with the potential to improve patient care. Antimicrobial stewardship programs have proven essential to embed such tests into clinical practice and thus support early appropriate antimicrobial therapy. Yet, the best implementation strategies for these tests are still unknown and likely dependent on the specific scenarios, […]

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CONCLUSIONS: This study highlights low awareness of EM guidelines and the presence of persistent system-level barriers to EM despite clinicians' positive attitudes and intentions. Findings suggest that stronger guideline dissemination, education, and practical supports are needed to embed EM into routine ICU practice. Future research should focus on implementation strategies and evaluation of safe, context-specific […]

We describe the rationale for using quantification of Gleason pattern 4 rather than the proportion of Gleason patterns for risk stratification in prostate cancer, as proposed by the ProQuant Group. We outline research that will be conducted to assess this strategy, and invite individuals interested in collaboration to join the group.

Bacterial phytopathogens, such as Pseudomonas syringae pv. tomato (Pst) DC3000, induce water-soaked lesions in the leaf apoplast under high humidity, facilitating infection. However, it remains largely unclear how plants regulate their resistance to restrict bacterial infection in response to humidity. Here, we demonstrate that abscisic acid (ABA)-catabolizing ABA 8'-hydroxylase, encoded by CYP707A3, plays a critical […]