Journal articles

OBJECTIVE: This parallel cohort-implementation study, termed MonitOring the health Trajectory of patients with kNee osteoarthritis (MOTION), aims to understand treatment pathways and outcomes for people with knee osteoarthritis referred to Australian public hospitals for orthopaedic assessment (Part A cohort study), and how improving access to first-line care might improve outcomes (Part B implementation study).

People with aphasia may present with cognitive impairments beyond language. In this population, reliance on language-based assessments of cognition may lead to unreliable metrics of cognitive performance across clinical and research settings. We investigated the underlying philosophy and practice of assessing cognition in people with aphasia. An e-survey was developed for multidisciplinary clinicians and researchers. […]

Rheumatic heart disease (RHD) has become exceedingly rare in the United States, but a recent resurgence may place military Servicemembers at increased risk for this diagnosis. Our case describes a 29-year-old U.S.-born Special Operations Forces (SOF) Soldier who presented for recurrent exertional near-syncope and progressive exercise intolerance with subsequent workup remarkable for RHD. Initial electrocardiogram […]

CONCLUSION: This scoping review contributes new findings to a body of international literature, while contributing a unique Australian perspective. These findings establish the foundations of an evidence base that supports inclusive clinical trial participation.

BACKGROUND: People with schizophrenia have a 16-20-year reduction in life expectancy, primarily due to cardiometabolic disease. Clozapine, the most efficacious antipsychotic for treatment-resistant schizophrenia, is associated with weight gain and metabolic dysfunction. Glucagon-like peptide-1 receptor agonists, including semaglutide, contribute to substantial weight loss in the general population, but their effect and safety profile in people […]

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CONCLUSION: Allogeneic SARS-CoV-2-specific T-cell therapy provides a platform to rapidly administer T cells to high-risk COVID-19 patients. It was associated with a reduced viral load and increased SARS-CoV-2-specific T-cell responses in the majority of treated patients.

Almost half of patients with triple-negative breast cancer (TNBC) develop distant metastases, heralding unfavorable outcomes. Here we provide novel insights into the contribution of the PI3K-mTOR pathway to the TNBC phenotypes that promote growth, migration, metastasis, and therapy resistance. Specifically, we demonstrate that dual targeting of PI3K and mTOR but not PI3K alone inhibits cancer […]

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Mycobacterium abscessus has been found in drinking water distribution systems worldwide, and infections have been increasing in frequency. The emergence of dominant circulating clones within clinical settings and during chronic disease has been considered a potential cause of the increasing frequency of disease. However, M. abscessus has been thought to be largely environmentally acquired, and […]

CONCLUSION: In this target trial emulation, bicarbonate administration was associated with a small but statistically significant reduction in mortality for patients with metabolic acidosis. Large sample sizes would be required to demonstrate this effect in a randomized trial.

Antifibrotic drugs, available for the best part of the last decade in many parts of the world, has improved outcomes in patients with idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. However, it is unclear whether patients suffering from these devastating conditions have timely and adequate access to antifibrotic therapy in the Asia Pacific region (APAC). […]

Individuals with monoallelic gain-of-function variants in the histone lysine methyltransferase DOT1L display global developmental delay and varying congenital anomalies. However, the impact of monoallelic loss of DOT1L remains unclear. Here, we sought to define the effects of partial DOT1L loss by applying bulk and single-nucleus RNA-sequencing, ChIP-sequencing, imaging, multielectrode array recordings, and behavioral analysis of […]