Journal articles

OBJECTIVE: Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy. We describe a novel Pol III-related disorder caused by monoallelic variants in […]

Skin temperature is fundamental in characterising human thermoregulatory responses. Wired probes, although accurate, restrict movement and are impractical outside laboratory settings. The iButton (DS1922L; Maxim Integrated, USA) is a widely used wireless alternative but does not meet the precision recommended by ISO 9886 and permits only retrospective data retrieval. A recently developed wireless sensor, the […]

CONCLUSION: A high proportion of resected PDAC patients experienced ER. Multiple pathological factors can predict ER. Primary tumor location was associated with site of recurrence. Neoadjuvant and adjuvant therapy significantly reduced ER and increased OS.

CONCLUSIONS: This review suggests that the common risk factors for foot disease-related hospitalisations are being male, having diabetes, chronic kidney disease, peripheral neuropathy, peripheral artery disease and lack of footcare, particularly in diabetes populations. There were no studies investigating hospitalisations for other foot-related conditions and few in nondiabetes populations.

CONCLUSIONS: The Roadmap is a rigorously co-developed, adaptable toolkit that can support equitable research partnerships. Findings justify formal effectiveness testing and implementation studies on scalability across settings to advance health equity.

CONCLUSION: A semi-automated dataset based on electronic health record documentation provides sufficiently accurate surveillance of central catheterisation related mechanical complications at the group level. Despite minor discrepancies, the semi-automated method enhances efficiency, scalability, and supports continuous real-time quality assurance. The potential underestimation of complication rates is offset by the possibility of robust real-time quality assurance […]

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CONCLUSIONS: Valganciclovir offers a cost-effective alternative to letermovir for preventing csCMVi in CMV-seropositive PTCy-based alloHCT recipients, with delayed count recovery precluding initiation as the major constraint for haplo-identical transplantation.

TMEM63B belongs to the OSCA/TMEM63 family of mechanosensitive ion channels. We recently identified it as a mechanosensitive lipid scramblase activated by changes in membrane physical properties. Cryo-EM analysis revealed that recombinant mouse TMEM63B (mTMEM63B) protein adopts either closed or open conformations depending on the detergent environment, and that the monoclonal antibody YN9303-24 stabilizes the open […]

CONCLUSIONS: In this real-world study, most piecemeal polypectomy was performed using cold snare technique. There was a clinically significant risk of recurrence in CA including those < 20 mm supporting current recommendations of surveillance at 6 months unless technical advances can be shown to reduce recurrence. Our findings suggest a lower risk of recurrence in […]

CONCLUSION: Baseline demographics from the IPF cohorts for both AILDR and AIPFR are largely comparable, with increasing antifibrotic and decreasing use of immunosuppressants since 2016. Immunosuppressive therapy in IPF remains relatively higher than expected despite guideline recommendations.

CONCLUSIONS: Respiratory-based physiotherapy services provided at night varied greatly across hospitals. On-call and evening-shift physiotherapists delivered multimodal treatments mostly to patients with a natural airway, located in the intensive care unit or hospital wards.

CONCLUSIONS: The present simulations show that breathing pattern influences intranasal airflow, air conditioning, rebreathed gas clearance, and sinus ventilation. Lower respiratory rates improved gas clearance by reducing the relative effect of anatomical dead space, while waveform differences also affected heat exchange and sinus transport. The findings should be interpreted as a mechanistic, case specific assessment […]

As the number of mitral valve transcatheter edge-to-edge repair procedures increases, there are catheter operators and interventional echocardiography operators performing these procedures with variable expertise. Expert imaging is paramount for the success of these procedures and requires knowledge of mitral valve anatomy, the ability to quickly manipulate two-dimensional (2D) and three-dimensional (3D) images in real […]

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