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Metro North is committed to providing a platform to acknowledge and promote research excellence within our health service. Below is a list of research publications from across our hospitals and services.
- Health-related quality of life outcomes from KEYNOTE-412: chemoradiotherapy with or without pembrolizumab in participants with head and neck squamous cell carcinoma 22 October 2025CONCLUSION: The addition of pembrolizumab to CRT did not meaningfully impact HRQoL in participants with LA HNSCC.J-P Machiels
- Equity in Access to Arthroplasty from a Gender Perspective: A Narrative Review 21 October 2025CONCLUSION: Achieving gender equity in arthroplasty requires systemic changes, including structured mentorship programs, leadership development workshops, and institutional commitments to diversity. Addressing implicit biases, promoting flexible training pathways, and fostering sponsorship programs for female surgeons are essential. A diverse workforce in arthroplasty will not only promote professional equity but also improve patient care and surgical […]Neha Patel
- Beyond the numbers: do nomograms capture the complexity of RRT dosing? Author's reply 21 October 2025No abstractManuel Colmenero
- No Causal Role for Premotor Cortex in the Perception or Misperception of Degraded Speech: Evidence from Transcranial Magnetic Stimulation 21 October 2025Although listeners can enhance perception by using prior knowledge to predict the content of degraded speech signals, this process can also elicit "misperceptions." The neurobiological mechanisms responsible for these phenomena remain a topic of debate. There is relatively consistent evidence for involvement of the bilateral posterior superior temporal gyri (pSTG) in speech perception in noise; […]Valeriya Tolkacheva
- Understanding internet-supported self-management for low back pain in primary care: a qualitative process evaluation of the SupportBack 2 randomised controlled trial 21 October 2025CONCLUSIONS: Digital interventions targeting physical activity and exercise to support LBP self-management may rely on mechanisms that are easily inhibited in complex, heterogeneous populations. Future research should focus on identifying and removing barriers that may limit the effectiveness of digital self-management support for LBP.Adam W A Geraghty
- Carotid Web Case Report: A Carotid Bifurcation Disorder Causing Stroke Without Localised Significant Stenosis 20 October 2025BACKGROUND: A 33-year-old gentleman presented to the Emergency Department with headaches and vertigo following neck manipulation with a chiropractor and was discharged following an unremarkable CT. Three weeks after the initial presentation, the patient re-presented within 24 h of a secondary neck manipulation, experiencing dysphasia and dysarthria.Samantha Hill
- Beyond Life's Essential 8: optimizing cardiovascular health metrics to predict mortality 20 October 2025CONCLUSIONS: Higher CVH is strongly protective against mortality. Refining LE8 scoring through rescoring and weighting can enhance mortality risk discrimination and reclassification, supporting improved CVH assessment for targeted prevention.Yang Peng
- Thyroid abscess: a rare complication following fine needle aspiration 20 October 2025Abscess is a rare pathology to affect the thyroid gland owing to several protective anatomical and physiological factors. Anatomical abnormalities of the thyroid, underlying thyroid pathology and an immunocompromised state have been known to be the leading risk factors associated with thyroid abscesses with only a few case reports noted secondary to trauma and iatrogenic […]Caitlin Sorour
- Small nerve fibre pathology in non-neuropathic chronic pain conditions: a systematic review and meta-analysis 20 October 2025Small nerve fibre pathology has been observed in several chronic pain conditions not typically classified as neuropathic (e.g., fibromyalgia). This systematic review compared morphometric data of small nerve fibres in people with non-neuropathic chronic pain conditions, defined using ICD-11 classifications, with pain-free controls. MEDLINE, EMBASE, Cochrane, Web of Science, and CINAHL were searched. Two independent […]Nayomi Ranathunga
- Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial 20 October 2025Adjuvant chemotherapy in stage III colon cancer provides uncertain benefit at the individual level. Circulating tumor DNA (ctDNA) may help refine risk-adjusted treatment selection. In this multicenter, randomized, phase 2/3 trial, patients with stage III colon cancer underwent ctDNA testing 5-6 weeks after surgery and were assigned (1:1) to ctDNA-guided or standard management. In the […]Jeanne Tie
- Determinants of empiric combination antibiotic therapy for hospital associated bloodstream infections in the intensive care unit 20 October 2025Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (ICUs) […]Evaldas Kauzonas
- Post-caesarean analgesia - a multicentre retrospective analysis comparing practices in Queensland, Australia (2019-2022) 19 October 2025CONCLUSIONS: Use of long-acting neuraxial opioid and oral atypical opioids increased, while commonly prescribed slow-release opioid declined with time. Compliance with opioid-sparing principles can be significantly improved.V A Eley
- Safety and performance of a novel defibrillation lead for left bundle branch area placement: primary results of the LEADR LBBAP clinical trial 19 October 2025CONCLUSIONS: These results demonstrate implantation of OmniaSecure lead when intended for LBBAP results in high defibrillation success at implant, stable short-term electrical parameters, and a low rate of OmniaSecure lead-related major complications at 3 months.Pugazhendhi Vijayaraman
- Implementing the Action Falls Program Into Care Homes in England (the FinCH Imp Study) 18 October 2025CONCLUSIONS AND IMPLICATIONS: Care homes were engaged and motivated to use Action Falls, which can be implemented with modest cost. Results emphasize the importance of ongoing support, digital integration, and policy backing to embed the Action Falls program into care homes. Overcoming logistical and technologic challenges is critical for its success.Fran Allen
- Does policy and practice for peripheral intravenous catheters match clinical standards? A point prevalence study 18 October 2025CONCLUSIONS: Despite a clear level of expected care for PIVCs, much unwarranted variation exists in policy and practice. Reform of local guidelines, policies, and processes to standardise PIVC care across hospitals and strategies to improve Standard adherence are needed.Josephine Lovegrove