Journal articles

The burden of hepatitis C virus (HCV) infection often falls disproportionately on migrant populations within high-income countries. Differences in health literacy, language, comorbidities, and HCV genotype may influence HCV natural history. 3537 persons including 652 migrants treated for HCV infection with direct-acting antiviral (DAA) (2016-2021) were analysed. We describe the epidemiology of HCV in migrant […]

CONCLUSION: Nested process evaluations of co-design are needed to support the continued theoretical and methodological development and resourcing of co-design in healthcare.

Cutaneous Mycobacterium haemophilum infection may be missed due to its requirement for iron supplementation and low-temperature incubation, making early consideration of NTM infection and use of molecular diagnostics essential, particularly in immunocompromised hosts where IRIS may mimic disease progression.

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CONCLUSIONS: In a heterogenous adult ICU population, the a priori predictive performance of vancomycin was shown to be acceptable. Conversely, the a priori predictive performance for the beta-lactams was not acceptable. Although predictive performance improved with the a posteriori approach for beta-lactams, only cefepime met acceptance criteria.

CONCLUSIONS: Screen-detected lung cancers show a stage shift towards earlier diagnosis and higher surgical treatment rates, supporting the potential effectiveness of the NLCSP.

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Beta-lactam antibiotics (beta-lactams) are first-line treatments for most major infectious syndromes in acutely ill patients, with in vitro activity against common pathogens, demonstrated efficacy in trials, and a perceived low risk of adverse effects. The current dosing approach, informed by population-level data, tends to be simplistically reduced to a "one size fits all" dosing method […]

CONCLUSION: This report supports the potential for CYP3A4 inhibition to aid with personalised ETI dosing strategies, particularly in low and middle-income countries where CFTRm access remains limited. Further research is needed to define optimal manipulation strategies, understand inter-individual variability in CFTRm metabolism, and evaluate the feasibility of therapeutic drug monitoring in diverse healthcare settings.

CONCLUSIONS: Maternal mental health is associated with multiple dimensions of offspring HRQoL across the life course. These findings highlight maternal mental health as an important correlate of offspring health and underscore the relevance of family-centred, preventive strategies aimed at reducing intergenerational inequalities in mental health.

CONCLUSION: The Framework shows promise for scale-up in remote and rural settings, as it aligns with the broader strategic and political context of opioid safety. However, the moderate to low scores across several implementation and resource-related domains highlight a range of potential issues that would need to be addressed prior to scale-up, including specific allocation […]

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia worldwide. Acute myocardial infarction (AMI) is closely intertwined with AF through a bidirectional relationship: pre-existing AF is associated with increased risk of AMI, while AMI predisposes to new-onset atrial fibrillation (NOAF). This narrative review synthesizes evidence on the global burden of AF in the setting of […]

Consciousness science faces the challenge of bridging first-person experience with third-person empirical measurements. Neurophenomenology aims to build such 'generative passages' connecting the content of experience with behavioural and neuroscientific data. However, the mathematical machinery for such bridges remains underdeveloped. Here we develop a Rosetta Stone hypothesis from predictive processing, where beliefs serve as a central […]

Cervical auscultation (CA), used an adjuvant to the clinical feeding examination by Speech-Language Pathologists (SLPs), has high sensitivity and reliability for detecting aspiration in neonates and children. CA can only be considered reliable if there are clear distinctions in the acoustic and perceptual swallow sound profiles between swallow sounds associated with and without aspiration. We […]

INTRODUCTION: Chronic kidney disease (CKD) is a significant global health concern, contributing substantially to mortality; in advanced stages, adults often require kidney supportive care (KSC), a model of care/intervention that addresses complex palliative and supportive needs. These needs often remain insufficiently addressed, particularly among adults receiving haemodialysis, due to the interplay of multiple contextual factors […]