Journal articles

CONCLUSION: The addition of pembrolizumab to CRT did not meaningfully impact HRQoL in participants with LA HNSCC.

CONCLUSION: Achieving gender equity in arthroplasty requires systemic changes, including structured mentorship programs, leadership development workshops, and institutional commitments to diversity. Addressing implicit biases, promoting flexible training pathways, and fostering sponsorship programs for female surgeons are essential. A diverse workforce in arthroplasty will not only promote professional equity but also improve patient care and surgical […]

No abstract

Although listeners can enhance perception by using prior knowledge to predict the content of degraded speech signals, this process can also elicit "misperceptions." The neurobiological mechanisms responsible for these phenomena remain a topic of debate. There is relatively consistent evidence for involvement of the bilateral posterior superior temporal gyri (pSTG) in speech perception in noise; […]

CONCLUSIONS: Digital interventions targeting physical activity and exercise to support LBP self-management may rely on mechanisms that are easily inhibited in complex, heterogeneous populations. Future research should focus on identifying and removing barriers that may limit the effectiveness of digital self-management support for LBP.

BACKGROUND: A 33-year-old gentleman presented to the Emergency Department with headaches and vertigo following neck manipulation with a chiropractor and was discharged following an unremarkable CT. Three weeks after the initial presentation, the patient re-presented within 24 h of a secondary neck manipulation, experiencing dysphasia and dysarthria.

CONCLUSIONS: Higher CVH is strongly protective against mortality. Refining LE8 scoring through rescoring and weighting can enhance mortality risk discrimination and reclassification, supporting improved CVH assessment for targeted prevention.

Abscess is a rare pathology to affect the thyroid gland owing to several protective anatomical and physiological factors. Anatomical abnormalities of the thyroid, underlying thyroid pathology and an immunocompromised state have been known to be the leading risk factors associated with thyroid abscesses with only a few case reports noted secondary to trauma and iatrogenic […]

Small nerve fibre pathology has been observed in several chronic pain conditions not typically classified as neuropathic (e.g., fibromyalgia). This systematic review compared morphometric data of small nerve fibres in people with non-neuropathic chronic pain conditions, defined using ICD-11 classifications, with pain-free controls. MEDLINE, EMBASE, Cochrane, Web of Science, and CINAHL were searched. Two independent […]

Adjuvant chemotherapy in stage III colon cancer provides uncertain benefit at the individual level. Circulating tumor DNA (ctDNA) may help refine risk-adjusted treatment selection. In this multicenter, randomized, phase 2/3 trial, patients with stage III colon cancer underwent ctDNA testing 5-6 weeks after surgery and were assigned (1:1) to ctDNA-guided or standard management. In the […]

Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (ICUs) […]

CONCLUSIONS: Use of long-acting neuraxial opioid and oral atypical opioids increased, while commonly prescribed slow-release opioid declined with time. Compliance with opioid-sparing principles can be significantly improved.

CONCLUSIONS: These results demonstrate implantation of OmniaSecure lead when intended for LBBAP results in high defibrillation success at implant, stable short-term electrical parameters, and a low rate of OmniaSecure lead-related major complications at 3 months.

CONCLUSIONS AND IMPLICATIONS: Care homes were engaged and motivated to use Action Falls, which can be implemented with modest cost. Results emphasize the importance of ongoing support, digital integration, and policy backing to embed the Action Falls program into care homes. Overcoming logistical and technologic challenges is critical for its success.

CONCLUSIONS: Despite a clear level of expected care for PIVCs, much unwarranted variation exists in policy and practice. Reform of local guidelines, policies, and processes to standardise PIVC care across hospitals and strategies to improve Standard adherence are needed.