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Metro North is committed to providing a platform to acknowledge and promote research excellence within our health service. Below is a list of research publications from across our hospitals and services.
- Patient-reported outcomes (PROs) as <em>personalised</em> cancer care: report from a 2023 Australian consensus meeting (PROActive) 7 July 2025This viewpoint reports on the outcomes of the 2023 Australian interest holder meeting on the use of patient-reported outcomes (PROs) in cancer care and discusses its findings in the context of the significant national investment into the collection of PRO data in Australia. The interest holders emphasised the importance for PRO data collection to be […]Carolyn G Mazariego
- Predictors of health-related quality of life among major trauma patients discharged from hospitals. A systematic review and meta-analysis 7 July 2025CONCLUSION: Predischarge factors, such as age, sex, preexisting conditions, and injury severity, are significant predictors of poor long-term HRQOL. Knowledge of these predischarge factors is important to improve long-term outcomes. Additional research should include hospital treatment and diagnostic factors.Zemedu Ferede
- Biopsy-free radical prostatectomy: a narrative review considering rationale, limitations, and current data 7 July 2025Prostate biopsy prior to radical treatment for prostate cancer is a common practice worldwide to allow diagnosis, prognostication, and treatment planning. However, recent advances in prostate multiparametric magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen (PSMA)-positron emission tomography (PET) have made the possibility of a "biopsy-free" radical prostatectomy, without prior biopsy, closer to reality than […]Arya Bahadori
- Experience with bioactive glass S53P4 (BAG-S53P4) granule implantation during the surgical management of spinal infection: Single-centre case series of 19 patients and brief review of literature 6 July 2025No abstractPatrick Pearce
- Development of a novel malignant colorectal polyp prognostic nomogram 5 July 2025CONCLUSION: This web-based nomogram will facilitate the discussion of whether individual patients with malignant colorectal polyps can be safely managed with polypectomy or whether the patient should undergo colorectal resection. This nomogram is now available at https://malignantpolyp.com/risk-calculator.Andrew P Zammit
- Rates of metabolic syndrome in Queensland adult community mental health consumers with schizophrenia and related disorders: A brief report 5 July 2025ObjectivePeople with schizophrenia are at increased risk of metabolic syndrome (MetS), contributing to excess morbidity and mortality. This study examined MetS monitoring rates and prevalence in people with schizophrenia receiving public mental health care in Queensland.MethodsData from the Consumer Integrated Mental Health and Addiction Application (CIMHA) were extracted for individuals aged 18-64 with a schizophrenia […]Mike Trott
- Visualizing Flow Dynamics in a Human Aorta During Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Treatment Through Particle Image Velocimetry Study 5 July 2025CONCLUSION: Pulsatile flow ECMO with better placement of ECMO pulse delivery in the cardiac cycle could develop greater pulsatility into the aorta, which is crucial for transferring haemodynamic energy and reducing cardiac afterload.Dhayananth Kanagarajan
- Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosis 5 July 2025BACKGROUND: Ataxia-telangiectasia (A-T) is a rare multisystem disease characterised by neurodegenerative cerebellar ataxia, lung disease, immune deficiency, high cancer risk, and mitochondrial dysfunction. A-T cells demonstrate defective endoplasmic reticulum-mitochondrial connectivity disrupting calcium homoeostasis and mitochondrial fusion, which are corrected in vitro by the triheptanoin metabolite, heptanoate.Matthew Lynch
- Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography and for Heart Failure With Preserved Ejection Fraction Diagnosis: An Update From the American Society of Echocardiography 5 July 2025Echocardiographic assessment of left ventricular (LV) diastolic function is an integral part of the routine evaluation of patients presenting with symptoms of dyspnea or clinical concerns for heart failure. Given the presence of diastolic dysfunction in many cardiovascular diseases, clinical reports should include comments on diastolic function and/or left atrial (LA) pressure whenever possible. Since […]Sherif F Nagueh
- Marginal cytokine modulation by Schistosoma mansoni soluble egg antigen in SARS-CoV-2-infected K18-hACE2 mice 4 July 2025Herein, we explore the potential influence of Schistosoma mansoni Sambon, 1907 soluble egg antigen (SmSEA) on the immunopathology of COVID-19 in K18-hACE2 mice infected with an Omicron BA.5 isolate of SARS-CoV-2. SmSEA treatment was delivered in a single dose by intraperitoneal injection, shortly after intrapulmonary inoculation of SARS-CoV-2. RNA-seq identified 36 differentially expressed genes in […]Yi Mu
- Administration of nivolumab plus ipilimumab: Infusion of the fixed-ratio combination versus sequential infusions in two randomized controlled trials of metastatic melanoma (CheckMate 742) and renal cell carcinoma (CheckMate 800) 4 July 2025CONCLUSIONS: Both studies met their primary endpoint. The safety profiles of nivolumab + ipilimumab as FRC or ASI were acceptable and manageable.Alexander M Menzies
- Understanding the acute care context to inform palliative care improvements: a qualitative study of hospital-based multidisciplinary clinicians 3 July 2025BACKGROUND: Population ageing and rising levels of non-communicable diseases are increasing the number of people living with and dying from advanced serious illnesses globally. Many of these people are hospitalised more than once in their last year of life. While there is sound evidence on what patients and their families require for safe and high-quality […]Claudia Virdun
- A Validation Study of the Paediatric Non-Urgent Risk Assessment Management and Nurse Escort Assessment (PaNURAMA) Tool for Paediatric Inter-Hospital Transfers 3 July 2025CONCLUSION: PaNURAMA demonstrates strong validity and reliability in risk stratification and escort allocation supporting its use in transfer decision making for non-critical paediatric IHTs.M Davison
- Sonographic Anatomy and Imaging of the Triangular Fibrocartilage Complex and the Distal Radio-Ulnar Joint 3 July 2025CONCLUSION: Improved understanding of the sonographic anatomy, technique and normal imaging appearances of ulnar-sided wrist structures can enhance the quality of imaging and subsequently the diagnosis of structural causes of pain, which can guide patient management.Craig Winnett
- Lower-limb biomechanics in motor neuron disease: a joint-level perspective of gait disruption 3 July 2025Background: Motor neuron disease (MND) profoundly impacts mobility, yet gait-specific dysfunctions due to MND remain poorly understood. Methods: We characterized lower-limb gait alterations in people living with MND (plwMND) using advanced biomechanical tools. Nine plwMND and nine non-neurodegenerative disease controls walked on an instrumented treadmill at self-selected speeds. Ground reaction forces and joint motions were […]Cory J Holdom