Journal articles

CONCLUSIONS: ATAL reconstruction enables the atlantoaxial joint to achieve sufficient stability while effectively preserving its ROM in all directions. This approach represents a paradigm shift from the current reliance on fusion techniques, which severely restrict atlantoaxial mobility, offering a novel therapeutic strategy for addressing AAI caused by TAL rupture.

The percutaneous kidney biopsy is an important skill in nephrology practice. Evidence-based material specifically discussing the procedural steps of a kidney biopsy is lacking. This article outlines the technical process and peri-procedural management of ultrasound-guided percutaneous kidney biopsy and is intended to serve as a useful and practical resource for nephrology trainees and consultants.

CONCLUSION: This study has produced insights into the high number of symptoms experienced during the initial four months of chemotherapy. Given the impact of symptoms on treatment outcomes, there is a critical need for the development of appropriate assessment tools capable of capturing this broad range of patient symptom experiences.

CONCLUSIONS: The study highlights the challenges faced by adults living with CKD and obesity. Provision of individualized support from trusted healthcare professionals can enhance participant experiences of LED interventions for adults with CKD and obesity. Findings support LED use in clinical practice and further research on its effectiveness in slowing CKD progression. Future weight loss […]

CONCLUSION: In a field often lacking high-quality data, these consensus statements from APLAR provide expert opinion-based guidance to support clinical decision-making. It is envisaged that it will assist in educational and training purposes and help shape future research priorities.

CONCLUSION: Incidental findings are common in preoperative CT scans performed for Mako robotic arm-assisted joint arthroplasty, particularly in THA patients. However, clinically significant findings are rare and infrequently alter surgical time frames. Surgeons should remain aware of the potential ethical and medicolegal implications of these findings.

RATIONALE: Tobacco smoking is a leading preventable cause of premature morbidity and mortality in people living with severe mental illness. Smoking rates are disproportionately high and abstinence rates low in people with severe mental illness, despite their reported interest in quitting being comparable to that of the general population. Inpatient psychiatry settings have been identified […]

CONCLUSIONS: HCWs broadly support AF screening, but differ in expectations regarding delivery roles, resources, and system readiness. Aligning AF screening programs with workforce preferences and organisational capacity is essential for scalable and sustainable implementation.

INTRODUCTION: Intrapartum antibiotics are often used to reduce neonatal risk of early-onset Group B Streptococcus (GBS) disease. Protocols aim to achieve a fetal serum and amniotic fluid concentration above the minimum inhibitory concentration (MIC) of GBS at the time of birth.

CONCLUSION: Kidney genetics care is expanding but remains unevenly implemented. Nephrologist-led models can be effective with support. Patient selection may influence diagnostic yield more than testing modality. Standardized outcome reporting and theory-driven implementation evaluation are essential for equitable and sustainable genomic services.

Sudden cardiac death, although infrequent, is a well-documented reality in young, often asymptomatic individuals. The risk of cardiac events is markedly amplified during high intensity physical activity, a circumstance commonly encountered in military environments. In this setting, undetected cardiovascular disease can have profound operational, safety, and morale consequences, particularly during high-demand duties where physiological stress […]

Single-cell RNA sequencing enables analysis of intra-tumoral transcriptional heterogeneity but has limited coverage of mutational hotspots. Here, we present LOTR-Seq, a protocol combining short-read whole-transcriptome analysis with long-read genotyping. We describe steps for hematopoietic stem cell isolation from human bone marrow samples, generation of full-length single-cell barcoded cDNA, target enrichment, and long-read sequencing for variant […]

CONCLUSIONS: Survey respondents indicated that current IHD guidelines do not address the needs of clinicians and patients in LMIC as effectively as they do for those in HIC. Respondents advocated for future guidelines to have specific recommendations for differing socio-economic environments, and consideration of cost reimbursement.

CONCLUSIONS: PaCT-ILD is a co-designed, needs-based referral aid that reflects real-world decision-making in ILD and offers a structured framework to support earlier, more consistent palliative care referral. Further evaluation is required to assess feasibility, acceptability, and impact on clinical outcomes.

Individuals with immunocompromising conditions or receiving immunosuppressive therapy are at increased risk for severe outcomes and complications from respiratory syncytial virus (RSV). An in-depth systematic investigation into severe RSV disease among immunocompromised adults is lacking. We therefore performed this systematic literature review to summarize the literature (2000-2024) on the burden of RSV disease across a […]