Journal articles

CONCLUSIONS: Future real-world studies should generate and comprehensively report implementation data across key domains, particularly program-level conditions that support sustainable, long-term integration of cessation into lung cancer screening. This is critical given that many lung cancer screening programs globally still have not implemented formal cessation supports. Strengthening the evidence base will inform scalable, context-specific approaches […]

CONCLUSIONS: The Quality Simulation Assurance Framework appears feasible, useful, and educative, supporting more consistent and culturally responsive simulation design. Further refinement should focus on strengthening guidance for co-design with Australian First Nations and New Zealand Māori and enhancing usability.

Introduction: Systematic endoscopic mediastinal lymph node (LN) staging in early stage non-small-cell lung cancer (NSCLC) is widely recommended for optimal pre-operative staging due to imperfect accuracy of PET/CT. The SEISMIC study utilized synoptic reporting of findings during systematic endoscopic staging to inform radiotherapy planning in patients with locally advanced NSCLC and established a significant rate […]

No abstract

New-onset atrial fibrillation (NOAF) frequently occurs in critically ill patients admitted to intensive care units (ICUs), yet definitions and outcome reporting remain inconsistent across clinical studies. This heterogeneity impedes evidence synthesis and limits the development of standardized management strategies. A scoping review was conducted following the Arksey and O'Malley framework and reported using PRISMA-ScR guidelines. […]

Meropenem is a valuable option for outpatient parenteral antimicrobial therapy (OPAT) due to its broad-spectrum activity, including multidrug-resistant Gram-negative bacteria, particularly when no oral alternatives exist. However, its conventional thrice-daily dosing poses logistical challenges for home administration, as the third dose typically falls during nighttime. This prospective pharmacokinetic study evaluated the adequacy of a novel […]

CONCLUSIONS: Rare but life-threatening ischemic and malignant arrhythmic AEs associated with PFA underscore the need for structured surveillance and standardized reporting. A deeper understanding of the underlying mechanisms will be essential to identify patients at risk and guide future studies aimed at further improving the safety of PFA.

CONCLUSIONS: In a single-centre heterogeneous population of critically ill adults with infection, initial dosing informed by a dosing nomogram for beta-lactams resulted in a high proportion of patients achieving therapeutic exposures.

CONCLUSIONS: This study highlights the complexity of PICC dressing and securement, demonstrating that nurses use a range of cognitive strategies that influence their practice.

BACKGROUND: Weight stigma is pervasive in maternity care, contributing to negative health outcomes and disengagement among larger-bodied women. To reduce weight stigma and promote respectful, individualized care, a weight-inclusive approach prioritizes overall well-being rather than focusing on weight as a key health indicator. How maternity care providers adopt weight-inclusive approaches remains underexplored. This study aimed […]

CONCLUSIONS: Among adult patients who presented to the emergency department with septic shock, an approach that involved restricted fluid volume and early vasopressors did not result in a greater number of days alive and out of the hospital at day 90 than an approach involving greater fluid volume and later administration of vasopressors. (Funded by […]

CONCLUSION: The utility of a registry relies on having meaningful and feasible data elements and indicators. Through involvement of key stakeholders in a systematic process, this study has selected data elements and indicators for a proposed AANZ pancreatic cancer surgery CQR. This is an essential step towards establishing such a registry. The next steps will […]

CONCLUSIONS: The nonparametric cefepime population PK model fit as a Bayesian prior in the holdout group. The optimal timing of PK sample collection varied according to regimen type and infusion duration. The precision of Bayesian estimates was lower for 0.5-hour infusions when samples were collected further from the model-predicted regimen-specific optimal collection times.

CONCLUSION: Carefully selected robust elderly patients with LA-HNSCC treated with chemoradiotherapy have outcomes comparable to younger patients after locally advanced head and neck cancer treatment.

BACKGROUND: MRI is recommended for men with clinical suspicion of significant prostate cancer. Those with high clinical risk but non-suspicious or equivocal MRI often undergo prostate biopsy, but have a low likelihood of clinically significant prostate cancer, and a high incidence of clinically insignificant prostate cancer. We aimed to investigate whether gallium-68 ([^(68)Ga]Ga)-prostate-specific membrane antigen […]