Journal articles

CONCLUSION: Vitamin D supplementation did not prevent PC progression, although reduced prevalence of CBMN markers may indicate a benefit of vitamin D supplementation.

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AmpC β-lactamases, found in certain Enterobacterales, confer resistance to third-generation cephalosporins, some β-lactam/β-lactamase inhibitor combinations, and cephamycins. They may be chromosomal or plasmid-mediated. Generally, third-generation cephalosporins are avoided in the treatment of high-risk AmpC producers, with cefepime or carbapenems being preferred for severe infections. Non-β-lactam options (fluoroquinolones, trimethoprim-sulfamethoxazole, and aminoglycosides) remain viable...

Novel technologies for the diagnosis of bloodstream infection are emerging, with the potential to improve patient care. Antimicrobial stewardship programs have proven essential to embed such tests into clinical practice and thus support early appropriate antimicrobial therapy. Yet, the best implementation strategies for these tests are still unknown and likely dependent on the specific scenarios, […]

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CONCLUSION: The limited data regarding late-onset hyperlactatemia make it difficult to draw significant conclusions regarding the relationship to clinical outcomes. However, the few available studies suggest that it is a common finding and highlight the need for further research to assess the underlying aetiologies and association with clinical outcomes.

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CONCLUSIONS: This study highlights low awareness of EM guidelines and the presence of persistent system-level barriers to EM despite clinicians' positive attitudes and intentions. Findings suggest that stronger guideline dissemination, education, and practical supports are needed to embed EM into routine ICU practice. Future research should focus on implementation strategies and evaluation of safe, context-specific […]

We describe the rationale for using quantification of Gleason pattern 4 rather than the proportion of Gleason patterns for risk stratification in prostate cancer, as proposed by the ProQuant Group. We outline research that will be conducted to assess this strategy, and invite individuals interested in collaboration to join the group.

Bacterial phytopathogens, such as Pseudomonas syringae pv. tomato (Pst) DC3000, induce water-soaked lesions in the leaf apoplast under high humidity, facilitating infection. However, it remains largely unclear how plants regulate their resistance to restrict bacterial infection in response to humidity. Here, we demonstrate that abscisic acid (ABA)-catabolizing ABA 8'-hydroxylase, encoded by CYP707A3, plays a critical […]

CONCLUSION: Regular self-collected nasal swabs for detecting respiratory viruses in a community setting is feasible in Australia and provides valuable information on asymptomatic infection.

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CONCLUSIONS: Elevated ventilatory ratio during SGOT was associated with unsafe weaning from VV-ECMO in this retrospective cohort of patients with ARDS. Prospective validation is warranted to inform future weaning practice.

CONCLUSION: Our study demonstrates no difference in the safety and efficacy profile of CF-PEEK nails as compared to titanium alloy nails in the management of oncological lesions of the femur. This needs to be interpreted with caution given the underpowered nature of this study. Furthermore, the current implant cost of CF-PEEK nails is prohibitive. Adequately […]