Journal articles

The 2025 European Society of Cardiology/European Association for Cardio-Thoracic Surgery guidelines mark a pivotal change, challenging the paradigm of symptom-driven watchful waiting, and supporting earlier treatment in many patients with asymptomatic severe aortic stenosis. Building on this foundation, this international expert perspective advocates a comprehensive, proactive management strategy and offers clinicians a contemporary operational framework […]

CONCLUSION: Future research evaluating whether prospective monitoring of upper-body function and interventions that can address impairment can reduce the risk of breast cancer-related lymphoedema are warranted.

BACKGROUND: There are few effective treatments for acute whiplash-associated disorder (WAD) following a road traffic crash. Early clinical features of central sensitisation, for example widespread hyperalgesia, predict poor recovery. Pregabalin's effects on central sensitisation suggest the potential to prevent or modulate these processes after whiplash injury and prevent later chronic pain. Preliminary evidence indicates that […]

We present a case of pregabalin toxicity in a 50-year-old dialysis-dependent female, who presented with a one-day history of progressive weakness, lethargy, and gait disturbance. They were successfully treated with haemodialysis. The case is notable for the atypical toxidrome seen in kidney failure, which occurred after a community pharmacy error led to a single twelvefold-increased […]

AbstractMultiple mechanisms underpinning biofilm antimicrobial resistance (AMR) have been studied individually. This study aimed to integrate these mechanisms, to understand their contributions to staphylococcal biofilm AMR, as a part of a whole, and to elucidate key hurdles hindering effective biofilm eradication by antimicrobial agents.Nine antibiotics were selected against microplate-based biofilms formed by Staphylococcus aureus ATCC […]

CONCLUSIONS: A dietitian-led preoperative VLCD intervention for 5-8 weeks can achieve clinically significant weight loss, primarily from fat mass. Exploratory analysis suggested lower preoperative fat mass may contribute to shorter surgical time, but further research is needed to control for other factors, such as complexity and surgeon experience.

CONCLUSIONS: This review highlighted wide variation in family-centred care interventions and outcome measures, with limited consistency in evaluation, replicability and quality. Family involvement in design was minimal, underscoring the need for more collaborative, co-designed initiatives.

CONCLUSION: In carefully selected patients with limited donor availability, lung transplantation may be considered in active COVID-19 infected patient, accompanied by a tailored regimen of antiviral therapy and immunosuppression.

CONCLUSIONS AND CLINICAL IMPLICATIONS: BCG + MM was not proved superior to BCG alone, but required 39% fewer doses of BCG and fewer treatment discontinuations. These findings support consideration of BCG + MM as a pragmatic alternative to BCG alone, which could mitigate the global shortage of BCG.

CONCLUSION: Integrated geriatric perioperative care is expanding globally but remains limited outside orthopaedics. Research should shift from improvement projects to rigorous implementation for sustainable transformation, including nurse-led models. Critical examination is needed of whether current outcomes address comprehensive needs of older surgical patients or primarily optimise hospital flow.

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CONCLUSIONS: It is encouraging that most Australian guidelines published during 2014-2025 reported at least some lived experience engagement in their development. However, extensive lived experience engagement was not reported for the vast majority of guidelines. The engagement of people with lived experience in guideline development needs to be improved to ensure that their values, views […]

Liver transplantation (LT) in critically ill patients with chronic liver disease is high risk. Recent studies show that the frequency of intensive care unit (ICU) LTs has risen, and outcomes of such transplants have improved significantly. Variation in practices and the impact of center experience with ICU LTs on outcomes is unknown outside of acute […]

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INTRODUCTION: The Osseointegration Group of Australia Accelerated Protocol-3 (OGAAP-3) presents the latest iteration of a structured, prospective, clinical-based protocol for single-stage osseointegration surgery in lower limb amputees. Building on the foundational work of OGAAP-1 and OGAAP-2, this protocol incorporates a decade of institutional experience and over 1000 cases using the Osseointegrated Prosthetic Limb system. OGAAP-3 […]