Journal articles

CONCLUSIONS: Actual body weight and RRT intensity and duration are the main determinants of vancomycin dosing requirements in critically ill patients treated with RRT. Efficacious, non-toxic dosing may be guided by the optimised nomogram.

CONCLUSION: A functional MRI paradigm including incorporation of novel task state has shown proof of principle in delirium. Whilst there has been previously shown to be hierarchical dissolution during delirium, there was no difference in functional brain activity shown in this study. The study was approved by the Metro North Reviewing Ethics Committee [Ref No: […]

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CONCLUSIONS: The study findings fill a gap in the evidence regarding challenges and recommendations for improving patient flow within hospital emergency departments and across the broader health system. Focussing efforts at the 'back end' of the inpatient journey is a critical step to improve emergency care outcomes.

CONCLUSIONS: In adults with Gram-negative bacterial BSI, cefiderocol was not superior to SOC based on DOOR or GPC analyses in both the main population and carbapenem-resistant subset. Integrating efficacy, safety and functional outcomes using these approaches provides a more comprehensive assessment than mortality alone.

CONCLUSION: The proportion of patients progressing to persistent opioid use after ED presentation was low and remained relatively stable, despite a substantial increase in the number of patients receiving at least one opioid prescription after an ED presentation. These results highlight the need for continued focus on appropriate prescribing and patient safety.

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People with cystic fibrosis (pwCF) experience a spectrum of glucose disorders. Spontaneous hypoglycaemia is a unique entity affecting pwCF and can be an incidental finding on biochemistry. Our prospective, single-arm pilot study of eight pwCF without confirmed diabetes and incidental biochemical hypoglycaemia found 62.5% demonstrated fasting or reactive hypoglycaemia on continuous glucose monitoring (CGM). The […]

CONCLUSION: Our education program was associated with an increased knowledge of appropriate clinical documentation of stroke. Ongoing monitoring of clinical coding and clinical documentation is required to ascertain whether the education of the participants translates to improved clinical coding of stroke.Implications for health information management practice:Accurate and complete clinical documentation directly impacts clinical coding, which […]

OBJECTIVE: Focal to bilateral tonic-clonic seizures (FBTC) are associated with significant morbidity and an elevated risk of sudden unexpected death in epilepsy (SUDEP). The cerebellum has been implicated in modulating the frequency and severity of tonic-clonic seizures. The present study aimed to identify alterations in cerebellar functional connectivity (FC) associated with susceptibility to FBTC in […]

CONCLUSIONS: As a comprehensive measure for evaluating subjective memory concerns in adults with epilepsy, the MMQ has demonstrated promising psychometric properties. However, future studies should clarify the dimensionality of the MMQ in this population and address measurement error, which could limit its utility in monitoring individual patients.

Extracellular vesicles (EVs) secreted by the host and polymicrobial oral community are natural endogenous biological nanoparticles that mediate host-microbe interactions. Given their abundance in biofluids, host, fungal and bacterial EVs circulating in saliva may reflect periodontitis-associated microbial dysbiosis and inflammation. In this study, salivary EVs from 20 healthy controls and 57 stages III/IV periodontitis were […]

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BACKGROUND AND OBJECTIVES: Weight stigma contributes to health inequity for pregnant women living in larger bodies. General practitioners (GPs) are an important gateway into maternity care. Our aim was to explore GP views on weight stigma in maternity care to inform recommendations for non- stigmatising care.