Journal articles

People with cystic fibrosis (pwCF) experience a spectrum of glucose disorders. Spontaneous hypoglycaemia is a unique entity affecting pwCF and can be an incidental finding on biochemistry. Our prospective, single-arm pilot study of eight pwCF without confirmed diabetes and incidental biochemical hypoglycaemia found 62.5% demonstrated fasting or reactive hypoglycaemia on continuous glucose monitoring (CGM). The […]

CONCLUSION: Our education program was associated with an increased knowledge of appropriate clinical documentation of stroke. Ongoing monitoring of clinical coding and clinical documentation is required to ascertain whether the education of the participants translates to improved clinical coding of stroke.Implications for health information management practice:Accurate and complete clinical documentation directly impacts clinical coding, which […]

OBJECTIVE: Focal to bilateral tonic-clonic seizures (FBTC) are associated with significant morbidity and an elevated risk of sudden unexpected death in epilepsy (SUDEP). The cerebellum has been implicated in modulating the frequency and severity of tonic-clonic seizures. The present study aimed to identify alterations in cerebellar functional connectivity (FC) associated with susceptibility to FBTC in […]

CONCLUSIONS: As a comprehensive measure for evaluating subjective memory concerns in adults with epilepsy, the MMQ has demonstrated promising psychometric properties. However, future studies should clarify the dimensionality of the MMQ in this population and address measurement error, which could limit its utility in monitoring individual patients.

Extracellular vesicles (EVs) secreted by the host and polymicrobial oral community are natural endogenous biological nanoparticles that mediate host-microbe interactions. Given their abundance in biofluids, host, fungal and bacterial EVs circulating in saliva may reflect periodontitis-associated microbial dysbiosis and inflammation. In this study, salivary EVs from 20 healthy controls and 57 stages III/IV periodontitis were […]

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Piperacillin-tazobactam is commonly used in critically ill pediatric patients; however, standard dosing regimens may not reliably achieve maximally effective exposures in this population. To characterize the population pharmacokinetics of piperacillin-tazobactam in critically ill pediatric patients and evaluate the adequacy of commonly used dosing regimens, plasma concentrations were obtained around a single dose of piperacillin-tazobactam in […]

Sex-specific penetrance in autosomal-dominant Mendelian conditions is largely understudied. The neurodevelopmental disorder Pilarowski-Bjornsson syndrome (PILBOS) was initially described in females. Here, we describe the clinical and genetic characteristics of the largest PILBOS cohort to date, showing that both sexes can exhibit PILBOS features, although males are overrepresented. A mouse model carrying a human-derived Chd1 missense […]

BACKGROUND AND OBJECTIVES: Weight stigma contributes to health inequity for pregnant women living in larger bodies. General practitioners (GPs) are an important gateway into maternity care. Our aim was to explore GP views on weight stigma in maternity care to inform recommendations for non- stigmatising care.

CONCLUSIONS: Of the patients who proceeded to post-IRE biopsy, 92% had infield ablation of clinically significant cancer with a low risk of urinary incontinence or impotence. Focal IRE of prostate cancer has promising short to medium-term outcomes and is associated with low risks of impotence and incontinence. Long-term follow-up of out-of-field progression risk is required.

CONCLUSIONS AND IMPLICATIONS: Following laryngectomy, a wide range of multidisciplinary services are accessed to support recovery and rehabilitation. Examining patient experiences through journey mapping has highlighted challenges that can influence the care pathway. Addressing issues that impact service access and patient experience will assist in enhancing laryngectomy care pathways and improve the patient experience.

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CONCLUSION: This review identified considerable variation in the clinical and technical design of digital HAI surveillance systems, with limited evidence of integration into clinical practice. While some studies reported improved surveillance efficiency, the absence of patient, quality and safety outcomes means it remains unclear which design approaches deliver the greatest clinical value. Future research should […]

BACKGROUND: The Asia Pacific region is home to more than half of the world's 1·93 billion adolescents (aged 10-24 years). Addressing adolescent health in this region is of global importance, but to date a systematic analysis of key contributors to disease in adolescents has not been done, which is a barrier to responsive action. This […]