Journal articles

The impact of the coronavirus disease 2019 (COVID-19) pandemic extended beyond direct infection-associated complications to wide-reaching impacts on health system including workflow disruption, enhanced telehealth utilization, labor force changes, and access to procedures. Whilst it is clear that COVID-19 can affect histopathological findings on kidney biopsy, the impact of COVID-19 pandemic on non-COVID-19 kidney disease […]

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CONCLUSIONS: The CHAT program was feasibly delivered within a public, health care context and resulted in positive and enduring changes in participants' language impairment, communication function, and quality of life.

CONCLUSION: Two learning modules co-designed and co-produced by health professional researchers, people with lived experience of stroke, and Stroke Foundation representatives led to improvements in knowledge and confidence for stroke researchers and those with lived experience of stroke to engage in collaborative research. Modules are freely available and compulsory for all researchers submitting Stroke Foundation […]

CONCLUSION: The impact of micronutrient supplementation on clinical outcomes is unclear, however, monitoring vitamin D levels and calcium intake after SCT should be considered to detect deficiency or inadequate intake.

CONCLUSIONS: A substantial proportion of mild stroke patients harbour treatable perfusion deficits. CT perfusion provides essential prognostic information beyond clinical severity, supporting its role in guiding therapeutic decisions-even in low NIHSS presentations where standard imaging may otherwise overlook tissue at risk.

CONCLUSIONS: This study reveals that dysregulated NAD⁺ metabolism, driven by increased PARP14 consumption, constitutes a potential mechanism underlying OA pathogenesis. Our findings support the concept that enhancing NAD⁺ availability via precursors or biosynthetic pathway modulation may offer disease-modifying effects at the molecular and histological level. Further investigation is needed to determine the functional and translational […]

BackgroundRinvecalinase alfa (DM199), a recombinant human tissue kallikrein-1 (KLK1), aims to promote local vasodilation to ischemic brain and enhance collateral blood flow. The ReMEDy1 trial tested the safety and tolerability of rinvecalinase alfa in ischemic stroke.MethodsReMEDy1 was a phase II, randomized, double-blind, placebo-controlled, study conducted at 13 Australian sites. Ninety-two patients with NIH Stroke Scale […]

CONCLUSIONS: The predictive score provides clinicians with an effective tool to support individualized linezolid therapy and guide TDM implementation, reducing the risk of toxicity or treatment failure.

Visual working memory is crucial for goal-directed thoughts and behaviors. However, it is not clear how goals modulate working memory maintenance, as previous models often considered stimulus encoding to be the endpoint of goal-directed control. To address this gap, eighty adults performed delayed estimation tasks while their brain activity was recorded using electroencephalography. In each […]

CONCLUSION: A large number of patients treated for infection in the ICU may be able to be included in a trial evaluating induced hyperthermia.

This study investigated the application of nanosecond pulsed electric field (nsPEF) treatment as an alternative pasteurisation method for donor human milk (DHM). A 0.1% saline solution was identified as the closest imitation to the received DHM in terms of pulse waveform and conductivity, which was used for the optimisation of PEF parameters. Complete inactivation of […]

BackgroundClinician engagement in research is shaped by research capacity building and organizational culture. This study aimed to assess current capacity and culture, and understand factors influencing research engagement.MethodsA sequential explanatory mixed-methods design was used, involving a Research Capacity and Culture (RCC) survey followed by interviews and focus groups at a major metropolitan tertiary hospital. All […]

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