Journal articles

CONCLUSION: An elevated NLR may be a surrogate marker for prolonged inflammation, highlighting the pathological role of dysregulated neuroinflammation, which can result in poor long-term functional outcomes. Further research should focus on elucidating the molecules driving pathogenic neuroinflammation after aSAH to highlight potential therapeutic targets.

CONCLUSION: A collaboratively designed course for sonographers has successfully been piloted, demonstrating positive results. This continuing education course is the first of its kind to equip sonographers for interprofessional ultrasound teaching in critical care settings.

CONCLUSION: Emergent antipsychotic use is associated with increased LOS, HACs and hospital mortality. These patients are also more likely to be discharged with new antipsychotics.

Myeloproliferative neoplasms (MPNs) are caused by acquired mutations in hematopoietic stem and progenitor cells (HSPCs). The acquisition of additional mutations like TP53 and the overall mutational burden influence a patient's risk of disease progression toward lethal post-MPN acute myeloid leukemia (AML). Recent technological advancements in linking single-cell gene expression with genotype have improved our understanding […]

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Neuropsychological assessments are traditionally conducted in person using standardised pen-and-paper methods. Technology has enabled computerised, tablet-based, and videoconference-based alternatives that improve accessibility for individuals in rural areas or with mobility issues. Despite promising developments, implementation has been slow. This scoping review was conducted to identify the barriers and facilitators associated with implementing technology in neuropsychological […]

CONCLUSIONS: The findings demonstrate that the care pathway cohort was associated with quicker return to modified duties without compromising long-term RTW outcome. This underscores the importance of proactive intervention strategies like care pathways in optimizing workplace rehabilitation outcomes and minimizing long-term disability. Clinical Trial Number Not applicable.

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Falls occur infrequently in critical care where the risk must be balanced against the advantages of physical therapy. Many falls risk assessment tools are not designed for use in critical care and often categorize all patients as "high risk" and thus their usefulness is limited. The Tyndall-Bailey Falls Risk Assessment Tool was specifically designed to […]

Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need for universal recommen- dations that address the unique challenges faced by patients and healthcare providers worldwide. Our iCARDIO Alliance Global Implementation Guidelines emphasize the […]

CONCLUSIONS: Our ex vivo findings demonstrate the feasibility of using sevoflurane vaporized directly into ECMO circuits as a sedative strategy. These results provide a robust foundation for translating this delivery strategy into a pilot clinical trial aimed at optimizing ECMO sedation with inhaled sevoflurane in patients with severe ARDS.

Floral nectary gland serves as an ecological hub, including a habitat for microorganisms introduced by pollinators. Although nectar supplies abundant carbon sources, it is limited in nitrogen sources. To address this unbalanced nutritional condition, it is considered that some nectar-dwelling bacteria including those belong to genus Acinetobacter obtain nutrients from pollen protoplasm by inducing pollen […]

CONCLUSIONS: This study suggests that achieving early therapeutic linezolid concentrations is associated with a higher likelihood of clinical cure and highlights the limitations of an initial standard dosing. In this scenario, an early TDM may help to identify patients out-of-range who need guided dosing to ensure the achievement of pharmacokinetic/pharmacodynamic targets. Further prospective studies are […]

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CONCLUSIONS: The GeneXpert system can effectively detect HPV in SOR samples. It offers rapid HPV detection, helps identify people at high risk of developing HPV-associated OPSCC, thereby holding promise for the early detection of HPV-driven OPSCC.