Journal articles

Treatment guidelines for open tibial fractures are well established in high-income countries, but their implementation in low-resource settings remains challenging. To date, only one African country has attempted to formulate national, consensus-based guidelines that cover key aspects such as antibiotic administration, initial stabilization, surgical debridement, wound management, and definitive fixation. This narrative review summarizes current […]

CONCLUSION: VHA use increased in both ED and inpatient settings, with prominent use in trauma and CLD. The results indicate growing recognition by clinicians of VHA's value in guiding haemorrhage management. The need for a consistent, evidence-based approach to testing and interpretation of results is paramount.

An 84-year-old Caucasian male was referred for evaluation of a worsening left medial canthal lesion for consideration of excision. The patient reported a 4-year history of the painless canthal lesion gradually increasing in size with progressively obstructed peripheral vision. On examination, the cream-colored cyst measured 10 × 8 mm. The best-corrected visual acuity with glasses […]

CONCLUSIONS: Participants consider many outcomes, spanning most of the ICF, to be important for children and adolescents with cognitive-communication disorders (CCDs). As children and adolescents age, the importance of ICF components shifts, and distinct outcomes emerge, highlighting the necessity of developmentally relevant rehabilitation. The broad range of outcomes reaching consensus reflects pediatric CCD complexity and […]

CONCLUSIONS: Thin-walled regions in intracranial aneurysms demonstrate a distinctive haemodynamic profile characterised by stronger, sustained shear forces, greater shear divergence, and reduced residence time, suggesting a dynamic mechanical environment that promotes focal wall thinning. Our findings suggest that persistent shear-driven stress, rather than oscillatory flow, is a key haemodynamic feature of thin-walled regions and may […]

CONCLUSIONS: Our systematic review demonstrated that HD-sEMG is a promising tool in assessing neuromuscular disorders as it can effectively distinguish individuals with neuromuscular disorders from healthy subjects.

BACKGROUND: Penicillin allergies are reported in 1 in 10 hospitalised patients globally and are associated with inferior patient and health service outcomes. However, more than 95% of low-risk penicillin allergies can be removed by direct oral challenge (DOC).

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The WNK-OSR1/SPAK protein kinase pathway regulates ion homeostasis and cell volume, but its other functions are not well understood. To discover undefined signaling functions, we utilized experimentally-derived binding specificity to predict interactions and relative affinities with the conserved C-terminal (CCT) domains of OSR1 and SPAK, which bind short linear motifs. The upstream kinases WNKs 1-4 […]

CONCLUSIONS: The multidisciplinary clinic was effective in improving participants' glycaemic control before elective noncardiac surgery. Individuals with the highest baseline HbA(1c) levels had the greatest preoperative improvement. This study highlights the meaningful impact on glycaemic management that can be achieved in the preoperative period. Parts of this work were previously presented at the 13th Australasian […]

CONCLUSIONS: Most post-resection surveillance colonoscopies for patients with colorectal cancer are performed earlier than recommended. Since colonoscopies in patients at low risk of cancer recurrence were generally performed too early, there is evidence of the potential overuse of healthcare resources and the opportunity to improve hospital efficiency.

CONCLUSION: Margins beyond 4 mm do not confer additional oncological benefit, while achieving ≥ 2 mm, especially in deep margins or high-risk tumors, is critical for optimal outcomes.

CONCLUSIONS: The MitraClip G4 system achieved significantly greater reduction of MR severity compared to the earlier generation mitral TEER device.

CONCLUSION: Generational differences as well as technology limitations affect the perception to virtual dental simulation. The acceptance of the Simodont® dental trainer is following the cycle of technology adoption models.

CONCLUSIONS: The peak risk of unplanned readmission occurred in the first few days after discharge, often for potentially preventable reasons such as hospital-acquired complications and recurrent heart failure. Such early and potentially preventable readmissions suggest many may be related to suboptimal quality of hospital care and discharge practices. Future clinical and policy interventions should target […]