Journal articles

Surfaces with programmable nanostructures represent a promising antimicrobial strategy that eradicates bacterial pathogens through physical membrane disruption and/or mechanically induced oxidative stress, independently of conventional antimicrobial resistance mechanisms. Despite their demonstrated and often potent in vitro efficacy, the successful clinical translation of this nanotechnology remains limited. Here, we synthesize the current understanding of how nanoscale […]

CONCLUSIONS: Hydrocortisone and methylprednisolone were cleared by CVVH, while tacrolimus, ciclosporin, and MPA Cl were negligible or absent. Hypoproteinemia and anemia significantly increased drug Cl. These findings provide mechanistic insights and support the need for validation in clinical studies to guide dosing during CKRT.

CONCLUSION: These findings underscore significant differences in results between ultrafiltration devices, depending on the drug, influenced by NSB. Such factors should be considered when developing methods for determining unbound concentrations of beta-lactam antibiotics.

CONCLUSIONS: MASLD is emerging as the leading cause of HCC while surveillance uptake remains suboptimal highlighting the importance of both at-risk MASLD case identification and the development of centralised HCC screening for improving the health of Australians. The significant variations in treatment patterns between LTCs and NTCs require further investigation and may provide insights that […]

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CONCLUSION: This evaluation highlights the potential of learner-driven, longitudinal models such as STARS to foster durable engagement with high-value care education and catalyse professional development among medical trainees.

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At present, there is no cure for the human genetic disorder ataxia-telangiectasia (A-T), which is managed by supportive care. This disorder arises due to mutations in the ATM (ataxia-telangiectasia mutated) gene and is characterised by a defect in the response to DNA damage, oxidative stress, mitochondrial dysfunction and immune deficiency. The ATM protein is activated […]

CONCLUSIONS: In Australia and New Zealand, delirium assessment practices have improved over time. Non-pharmacological strategies are widely used; however, antipsychotic use remains substantial. Workforce constraints, education gaps and system pressures may contribute to variability in delirium care delivery. Addressing these factors, alongside engagement with carers, may support further improvements in care. Ongoing surveillance through repeated […]

CONCLUSIONS: Findings provide preliminary evidence of an unmet need for interventions to support lifestyle behaviour change among those with insomnia symptoms. While support is acceptable to many, targeted approaches may be needed for subgroups with lower adherence and acceptability.

Watchful waiting (WW) in low tumour burden follicular lymphoma (LTB FL) defers treatment. There is a need to develop a model to predict time to treatment (TTT). We aimed to develop and externally validate a model for TTT in LTB FL. We conducted a retrospective analysis across eight centres within the Australasian Lymphoma Alliance. Two […]

Fluoroscopic systems are increasingly used for complex image-guided procedures across medical disciplines in Australia and New Zealand. The associated radiation exposure risks to patients and staff necessitate robust quality assurance (QA) programs. However, no national guidance has previously existed for a standardised fluoroscopy QA program in the Australia and New Zealand context. To provide evidence-informed […]

CONCLUSIONS: The final study results of the LEADR LBBAP clinical trial demonstrate a continued stable electrical performance, low rate of lumenless defibrillation lead-related major complications, and LOT-CRT therapy benefit when a lumenless defibrillation lead is implanted for LBBAP.

Pre-clinical evidence suggests that stereotactic ablative body radiotherapy (SABR) can enhance systemic anti-tumor responses when combined with immune checkpoint inhibition, although optimal fractionation remains uncertain. Here we conducted a phase II multi-center randomized trial (AZTEC trial; ClinicalTrials.gov identifier NCT03464942) to investigate the efficacy and safety of single-fraction (SF: 20 Gy; n = 27) or multi-fraction […]

Addressing society's greatest challenges, such as climate change, requires us to act as moral agents. If effective, interventions within schools and universities could cultivate ethical and moral attributes in millions of people. This systematic review and meta-analysis, preregistered on the Open Science Framework ( https://osf.io/bdn2u ), synthesizes evidence from 92 randomized controlled trials conducted in […]