Journal articles

Herein, we explore the potential influence of Schistosoma mansoni Sambon, 1907 soluble egg antigen (SmSEA) on the immunopathology of COVID-19 in K18-hACE2 mice infected with an Omicron BA.5 isolate of SARS-CoV-2. SmSEA treatment was delivered in a single dose by intraperitoneal injection, shortly after intrapulmonary inoculation of SARS-CoV-2. RNA-seq identified 36 differentially expressed genes in […]

CONCLUSIONS: Both studies met their primary endpoint. The safety profiles of nivolumab + ipilimumab as FRC or ASI were acceptable and manageable.

BACKGROUND: Population ageing and rising levels of non-communicable diseases are increasing the number of people living with and dying from advanced serious illnesses globally. Many of these people are hospitalised more than once in their last year of life. While there is sound evidence on what patients and their families require for safe and high-quality […]

CONCLUSION: PaNURAMA demonstrates strong validity and reliability in risk stratification and escort allocation supporting its use in transfer decision making for non-critical paediatric IHTs.

CONCLUSION: Improved understanding of the sonographic anatomy, technique and normal imaging appearances of ulnar-sided wrist structures can enhance the quality of imaging and subsequently the diagnosis of structural causes of pain, which can guide patient management.

Background: Motor neuron disease (MND) profoundly impacts mobility, yet gait-specific dysfunctions due to MND remain poorly understood. Methods: We characterized lower-limb gait alterations in people living with MND (plwMND) using advanced biomechanical tools. Nine plwMND and nine non-neurodegenerative disease controls walked on an instrumented treadmill at self-selected speeds. Ground reaction forces and joint motions were […]

CONCLUSIONS: Closely monitoring SpO(2) resulted in early weaning and reduced the use of and exposure to oxygen. Where oxygen supplies are at a premium, this approach may improve equitable access for children with severe pneumonia.

CONCLUSION: Tracheal rings can be identified by distinctive sonographic features. Inner tracheal width may be estimated by averaging the diameters of the outer-tracheal border and its reflection within the air column. Further clinical studies of relevant patient populations are needed to determine accuracy and reliability of estimates.

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BACKGROUND: Nicotine-containing electronic cigarettes (e-cigarettes) have been shown to be effective for smoking cessation among general populations, but there is little evidence in people with substance use disorders (SUDs). We aimed to assess the effectiveness of e-cigarettes for smoking abstinence in people with SUD following discharge from smoke-free inpatient withdrawal services.

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INTRODUCTION: Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk of infection due to immunosuppression, prompting routine use of prophylactic and broad-spectrum antibiotics for treatment. However, emerging evidence suggests that gut microbiome disruption (dysbiosis), partly caused by antibiotic use, is associated with poorer transplant outcomes, including graft-versus-host disease (GVHD), infection, and mortality.

Infectious uveitis remains a major cause of global visual morbidity, with significant geographic variability in its epidemiological patterns and clinical presentations. The Asia-Pacific region presents a unique model to study infectious uveitis, due to socioeconomic, environmental, and healthcare diversity within its populations. This narrative review explores the spectrum of infectious uveitides prevalent in the Asia-Pacific […]

CONCLUSION: ML integration of comprehensive echocardiographic data with clinical data could lead to improved prediction of survival following MI. Clinical implementation should be considered.

Central blood pressure can be estimated non-invasively using radial applanation tonometry. However, the stability and accuracy of applanation tonometry signals is operator-dependent. We examined the concordance between finger and radial artery pressure waveforms captured using an automated, beat-by-beat, photoplethysmograph device (Finometer PRO) and radial applanation tonometry respectively, to estimate central pressure waveform characteristics including systolic […]