Journal articles

Background/Objectives: Medication errors (MEs) in intensive care units (ICUs) remain a persistent threat to patient safety. A significant surveillance gap exists where traditional voluntary reporting detects as few as 0.02 MEs per patient-day, leaving approximately 98% of errors invisible to standard audits. This review critically examines how artificial intelligence (AI) and implementation science can bridge […]

Background/Objectives: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Electrolyte disturbances are common in this patient cohort, with serum chloride frequently elevated. Chloride dysregulation may be associated with poor neurological outcomes through mechanisms including paradoxical gamma amino butyric acid receptor excitation, cytotoxic edema, and ferroptosis. The aim of this review […]

Quantifying the challenges of intensive care work remains difficult. Conventional data fails to capture the realities of the intensive care unit (ICU) environment, and without identification of the problem, there is little chance of a solution. This paper presents novel workforce and operational data from a large Australian ICU, illustrating the complexity, unpredictability, and ethical […]

CONCLUSIONS: Adding vancomycin to cephazolin prophylaxis in arthroplasty is most likely not cost-effective. Omitting vancomycin could lead to substantial annual savings for the healthcare sector without compromising health outcomes.

'Chemobrain' language symptoms are commonly reported by adults receiving intensive chemotherapy for acute myeloid leukaemia (AML), but real-time detection eludes clinical imaging modalities. We performed a prospective, observational, longitudinal cohort study employing serial comprehensive neurocognitive assessment and brain functional MRI (fMRI) in 20 adults receiving intensive chemotherapy for newly diagnosed AML. At chemotherapy completion, fMRI […]

CONCLUSION: Access to physiotherapy for pwPD is limited and occurs later in the disease process. The findings suggest that early individualised education, staff training, identification and provision of suitable physiotherapy services close to patients' homes could improve access.

Cystic fibrosis (CF) modulator therapies can lead to rapid and excessive weight gain. Obesity in CF can lead to undesirable metabolic complications including type 2 diabetes. Therefore, glucagon-like peptide 1 (GLP-1) agonists which can facilitate weight loss and improve metabolic profiles are increasingly prescribed to people with CF. We present the first case report documenting […]

CONCLUSION: Awareness of the spinal accessory nerve anatomy and imaging appearances is required when sonographically imaging the neck to identify the spinal accessory nerve, ensuring it is not in the needle path during ultrasound-guided neck biopsies and identifying any potential injury or pathological involvement.

CONCLUSIONS: AI chatbot-assisted flipped learning effectively improved students' handover competency. Integration of the AI chatbot promoted reflective learning. The study presents an innovative strategy for preparing students for clinical communication.

CONCLUSIONS: Certain antibiotics and NSAIDs may disrupt ameloblast integrity and enamel biomineralization in experimental animal models. These findings are hypothesis-generating, and further well-designed human observational and mechanistic studies are required before clinical translation.

CONCLUSIONS: Delayed ICU admission was significantly associated with increased mortality, particularly in patients with elevated SOFA scores, indicating worsening organ dysfunction and clinical instability.

CONCLUSIONS: Incorporating the FRAIL Scale Tool into the annual health assessment for people aged 75 years and older provides a funded opportunity for addressing frailty in general practice. Patients and staff value the Tool's simplicity and the opportunity to raise awareness and manage frailty proactively. Incorporating the Tool into practice software systems would enhance adoption. […]

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There are a number of guidelines on how to manage obesity, but inconsistencies in healthcare access, varying infrastructure, resource constraints, and diverse local practices restrict their global applicability. This underscores the need for universal recommendations that address the unique challenges faced by patients and healthcare providers worldwide. Our Global Guidelines emphasize the incorporation of novel […]

The complement system is a conserved network of plasma and membrane-associated proteins that supports immune defense and tissue homeostasis. In multiple sclerosis (MS), persistent complement activation contributes to neuroinflammation, demyelination, and axonal injury. However, the translation of complement-targeted therapies for MS treatment has been limited, largely due to uncertainty surrounding the complex and context-dependent roles […]