Journal articles

BACKGROUND: Delirium, a common, serious and often preventable complication in older hospitalised adults, contributes to significant health and social care costs. Carers are uniquely positioned to identify early signs and support delirium prevention. The Prevention & Early Delirium Identification Carer Toolkit (PREDICT), a novel model of care designed to educate carers about delirium management and […]

CONCLUSIONS AND RELEVANCE: Through a methodologically robust development process, the SOFA-2 score offers updated definitions to describe organ dysfunction in adult patients requiring critical care and readily quantifiable criteria to grade the degree of dysfunction in individual organ systems. This score considers contemporaneous changes in patient management and outcomes.

CONCLUSIONS AND RELEVANCE: The SOFA-2 score, updated to include contemporary organ support treatments and new score thresholds, describes organ dysfunction in a large, geographically and socioeconomically diverse population of critically ill adults.

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CONCLUSIONS: Our findings support a shift towards trajectory-based stratification in clinical care and research. Incorporating these patterns into prognostic modelling may improve outcome prediction, personalise rehabilitation and refine eligibility criteria for interventional trials.

CONCLUSION: In BCR PCa, RECIP 1.0 best predicts OS, PPP criteria better predict PSA progression, and PROMISE nomograms provide a single-timepoint approach to OS risk stratification.

CONCLUSIONS: Infection incidence is very low but remains a serious risk, mainly for complex patients. Gram-negative organisms may now be predominant in Australia. Infection surveillance should be risk-adjusted and prevention efforts to improve both insertion and post-insertion management targeted at high-risk groups. While overall intravenous therapy (exposure) should be minimised, daily risk per PIVC appears […]

CONCLUSION: Fever deficits were large, particularly when the initial body temperature was not febrile. Only 1 in 15 ICU patients with sepsis had an initial body temperature ≥38.3°C. Approximately 2000 adults a year with sepsis and an initial body temperature

CONCLUSION: Alternate consent models for critical care RCTs were associated with higher recruitment rates compared to a priori consent. A study-within-a-trial analysis may be required for definitive evaluation.

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Almost fifty years after the identification of ataxia telangiectasia (A-T) as a radiosensitive disorder and thirty years following the identification of ataxia telangiectasia mutated (ATM) as the defective gene, clinicians and scientists gathered at Loughborough University, UK from June 25th -27th 2025 for an Ataxia Telangiectasia Clinical Research Conference. The mix of expertise of clinicians […]

CONCLUSIONS: This exploratory study demonstrated that NSPT led to clinical improvements accompanied by changes in the composition and cytokine cargo of salivary host EVs. Alterations in salivary host EV sub-populations and cytokine profiles may have potential utility as biomarkers for monitoring treatment outcomes in periodontitis.

CONCLUSION: In this Phase 1 trial, topical application of botulinum toxin via spray was shown to be safe, without any significant adverse events. It reduced the TNSS and VAS across the cohort. However, the treatment efficacy should be taken in context as there was no blinding, alternative dosing, or comparison against placebo or recognized active […]

CONCLUSION: Early dietary changes after bariatric surgery seem to be influenced by psychological, social, and physical factors beyond education. Future interventions should aim to incorporate strategies to reduce cognitive load, address competing social pressures, and account for the temporal aspects of health-protective behaviours. Theory-based interventions that integrate implementation intention techniques, social support optimisation, and temporal […]