Journal articles

Acute hyperkalaemia is a medical emergency requiring rapid clinical evaluation. Point-of-care blood gas analysis may overestimate serum potassium concentration and should be confirmed with a laboratory sample unless urgent treatment is required. When ECG (electrocardiogram) changes are present, immediate cardiac protection is a priority. Current guidelines recommend administering intravenous 10% calcium gluconate to restore cardiac […]

Cardiac amyloidosis is an under-recognised but treatable condition characterised by insoluble protein deposition in the heart and is associated with high morbidity and mortality. It is most commonly caused by transthyretin (known as transthyretin [ATTR] amyloidosis) but may also be caused by a plasma cell dyscrasia (known as light chain [AL] amyloidosis). Cardiac amyloidosis should […]

Background An Acute Resuscitation Plan (ARP) is a document that helps medical professionals incorporate the wishes of patients and their families, as well as the opinions of the treating team, when making decisions about treatment escalation and whether resuscitation is appropriate should a patient clinically deteriorate. This project aimed to assess if the use of […]

Repeated molecular sampling of the distal airways is constrained by the invasive nature of bronchoalveolar lavage (BAL), limiting its use in healthy control populations, longitudinal studies, clinical trials and occupational screening. Particles in exhaled air (PExA) sampling offers a non-invasive approach to distal-airway sampling, although whether it captures the same proteins and relative protein abundance […]

CONCLUSION: Workplace-related and personal factors significantly influenced maternity and neonatal staff well-being during the pandemic. Addressing workplace stress, promoting sleep, supporting healthy coping mechanisms, and encouraging restorative activities may improve staff well-being. These findings can inform the design of targeted workforce support programs and guide service planning strategies to strengthen resilience during future system shocks.

CONCLUSIONS: Medication adverse events due to potentially error-prone steps in medication management processes are a common cause of inpatient MERT activations, presenting a considerable preventable burden to patients and healthcare resources.

PURPOSE OF REVIEW: This narrative review summarises current knowledge of weight stigma in pregnancy including consequences, drivers, and potential solutions.

Laplace-based methods define cortical thickness as the length of a streamline connecting the pial and white surfaces, but existing implementations discretize the volume and lose accuracy in tight folds. Surface-based methods use Euclidean inter-surface distances that cannot enforce orthogonal, non-crossing correspondences. We solve Laplace's equation on the cortical surface itself using a boundary element method, […]

CONCLUSION: The absence of evidence-based guidance to manage troubleshooting and catheter dysfunction places substantial burden on ICU nurses. Evidence-based troubleshooting decision tools may have the potential to improve dialysis efficiency, reduce healthcare-associated risks and workforce stress.

Physical health assessment and investigations are important considerations during the first episode of psychosis. These activities support diagnostic clarification, monitoring for iatrogenic harms and opportunistic screening to limit the multimorbidity that is often associated with psychotic disorders in the longer term. The recent 'Australian and New Zealand Journal of Psychiatry Grading of Recommendations, Assessment, Development […]

We previously reported the results of a multicenter phase II trial (ClinicalTrials.gov identifier: NCT04154943) of neoadjuvant cemiplimab in resectable stage II to IV cutaneous squamous cell carcinoma (CSCC), in which the pathologic complete response (pCR) rate was 51%. At the 19-month follow-up, estimated 12-month event-free survival (EFS) was 89%, with 11 EFS events. In this […]

ObjectivesPeople with Parkinson's disease (PD) are at increased risk of delirium. Documentation of delirium is poor, with challenges in making a diagnosis due to overlapping symptoms. This study interviewed healthcare workers about their experiences of caring for inpatients with PD and delirium to explore their perspectives.DesignA qualitative study with semi-structured interviews and thematic analysis.ParticipantsTwelve healthcare […]

CONCLUSIONS/INTERPRETATION: Maternal obesity, rather than type 2 diabetes, may be the major determinant of reduced breastfeeding rates 4 months postpartum.

CONCLUSIONS: NSPT led to changes in salivary host and non-host EV cargoes, suggesting that they may serve as a non-invasive tool for disease treatment monitoring in periodontitis.

[^(212)Pb]Pb-ADVC001 (^(212)Pb-ADVC001) is a prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy with high linear energy transfer derived predominantly from the alpha-emission of its ^(212)Pb payload which, upon decay, delivers potent ionizing radiation directly to the tumor. TheraPb (NCT05720130) is a first-in-human dose-escalation and optimization study evaluating ^(212)Pb-ADVC001 in metastatic androgen pathway modulation-resistant prostate cancer (mAPM-R, formerly...