Journal articles

CONCLUSION: A semi-automated dataset based on electronic health record documentation provides sufficiently accurate surveillance of central catheterisation related mechanical complications at the group level. Despite minor discrepancies, the semi-automated method enhances efficiency, scalability, and supports continuous real-time quality assurance. The potential underestimation of complication rates is offset by the possibility of robust real-time quality assurance […]

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CONCLUSIONS: Valganciclovir offers a cost-effective alternative to letermovir for preventing csCMVi in CMV-seropositive PTCy-based alloHCT recipients, with delayed count recovery precluding initiation as the major constraint for haplo-identical transplantation.

TMEM63B belongs to the OSCA/TMEM63 family of mechanosensitive ion channels. We recently identified it as a mechanosensitive lipid scramblase activated by changes in membrane physical properties. Cryo-EM analysis revealed that recombinant mouse TMEM63B (mTMEM63B) protein adopts either closed or open conformations depending on the detergent environment, and that the monoclonal antibody YN9303-24 stabilizes the open […]

CONCLUSION: MNP contamination may substantially increase the clinical and economic burden associated with carotid endarterectomy in Australia. Although model-based and subject to uncertainty arising from potential false positives of MNPs due to challenges with analysis in tissue matrices, these findings highlight MNPs as a plausible, previously unrecognised contributor to adverse vascular outcomes and healthcare expenditure.

CONCLUSIONS: Symptom presentation in AMI is heterogeneous, and reliance on "classic" symptoms alone may miss at-risk patients. While some differences in individual symptom associations were observed for Aboriginal and Torres Strait Islander patients, overall cluster patterns were comparable.

CONCLUSION: This retrospective cohort study undertaken across multiple metropolitan centres shows increased uptake of TNT, particularly in high-risk patient cohorts, consistent with changes in international guidelines for treatment of rectal adenocarcinoma.

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SUMMARYRoss River virus (RRV) causes the most mosquito-borne disease notifications in Australia and a considerable burden of non-fatal, yet frequently prolonged rheumatic illness across the Australia-Pacific region, reflected in thousands of notifications each year and notable economic and quality-of-life losses. Research on RRV spans multiple disciplines, encompassing viral genomics, immunopathology, transmission ecology, epidemiology, entomology, and […]

CONCLUSIONS: In this real-world study, most piecemeal polypectomy was performed using cold snare technique. There was a clinically significant risk of recurrence in CA including those < 20 mm supporting current recommendations of surveillance at 6 months unless technical advances can be shown to reduce recurrence. Our findings suggest a lower risk of recurrence in […]

CONCLUSION: Baseline demographics from the IPF cohorts for both AILDR and AIPFR are largely comparable, with increasing antifibrotic and decreasing use of immunosuppressants since 2016. Immunosuppressive therapy in IPF remains relatively higher than expected despite guideline recommendations.

CONCLUSIONS: Respiratory-based physiotherapy services provided at night varied greatly across hospitals. On-call and evening-shift physiotherapists delivered multimodal treatments mostly to patients with a natural airway, located in the intensive care unit or hospital wards.

CONCLUSIONS: The present simulations show that breathing pattern influences intranasal airflow, air conditioning, rebreathed gas clearance, and sinus ventilation. Lower respiratory rates improved gas clearance by reducing the relative effect of anatomical dead space, while waveform differences also affected heat exchange and sinus transport. The findings should be interpreted as a mechanistic, case specific assessment […]

As the number of mitral valve transcatheter edge-to-edge repair procedures increases, there are catheter operators and interventional echocardiography operators performing these procedures with variable expertise. Expert imaging is paramount for the success of these procedures and requires knowledge of mitral valve anatomy, the ability to quickly manipulate two-dimensional (2D) and three-dimensional (3D) images in real […]

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