Journal articles

BackgroundFalls are a significant challenge in inpatient hospices, with serious consequences including injury, loss of confidence, prolonged admissions, and reduced quality of life. The Action Falls Programme, a multifactorial falls prevention intervention, has proven effective in UK care homes. However, hospice patients present distinct risks related to their complex, palliative care needs, necessitating adaptation of […]

CONCLUSION: Clinicians must have a high index of suspicion for ACS in Aboriginal and Torres Strait Islander people with chest pain who present with symptoms of gastrointestinal upset such as indigestion or vomiting. Typical or atypical groupings of ACS symptoms are of limited value or relevance in Australian populations, and these terms should be phased […]

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CONCLUSION: Nasogastric administration and non-fasting states may reduce nimodipine's bioavailability. CSF penetration was minimal and highly variable. The population pharmacokinetic model identified age as a significant determinant of clearance. Optimizing the administration of nimodipine may be required. Further large-scale studies focusing on the definition of nimodipinés optimal dosing are warranted.

CONCLUSIONS AND CLINICAL IMPLICATIONS: Annual PSA screening in BRCA2 PGV carriers confirmed a higher incidence of csPC and detection of clinically relevant tumours in comparison to noncarriers. For the first time, we confirm that PSA screening in BRCA1 PGV carriers results in early detection of NCCN IR-U/HR PC. Systematic PSA screening is recommended for BRCA2 […]

CONCLUSION: Vedolizumab trough levels were not associated with clinical or objective remission during maintenance therapy, and in our real-world cohort, do not appear to be a clinically relevant target for TDM.

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The report from the American Association of Physicists in Medicine (AAPM) Task Group 132, published in 2017, established a framework and recommendations for the safe implementation of rigid image registration (RIR) and deformable image registration (DIR) into radiation oncology clinical practice. The Medical Image Registration Special Interest Group (MRSIG) of the Australasian College of Physical […]

CONCLUSIONS: This research highlights the lethality of explosive weapons among local casualties, with a case fatality rate significantly higher than that observed in high-resource civilian or military trauma systems, illustrating the deadliness and indiscriminate nature of these devices. The findings of this analysis can inform injury prevention and trauma care initiatives targeting preventable death and […]

This systematic review investigated the benefits and risks of using ChatGPT to simplify radiology reports to enhance patient understanding. PubMed/MEDLINE, Embase, Web of Science, and CENTRAL databases were searched for studies published until December 17, 2024. In total, 16 studies met eligibility criteria for inclusion, where ChatGPT utilised the GPT-4 model in 10 studies (63%), […]

CONCLUSIONS: The process evaluation indicates high acceptability of the EDDIE + intervention. However, fidelity and intended mechanisms of impact were mixed despite substantial pre-planning prior to implementation. For future studies, specific barriers in the RAC setting such as staffing and turnover may be unable to be adequately addressed without systemic change.

In this retrospective analysis of 584 patients who received CAR T-cell therapy for LBCL at six Australian centres we found no association between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.

The spermatheca is a specialized organ for sperm storage and is essential for reproductive success, particularly in ants, where queens preserve the viability of stored sperm for over a decade. However, the process of establishing the physiological environment and morphology of the spermatheca that enable long-term sperm storage remains largely unexplored. This study demonstrated that […]

CONCLUSION: The non-steroidal MRA finerenone reduced the rate of cardiovascular death and total heart failure events under both frequentist and Bayesian inference methods. The probability of benefit exceeded 80% for both cardiovascular and all-cause mortality with finerenone.