Journal articles

Hydrogen has emerged as a therapeutic agent in inflammatory critical illnesses due to its potential to modulate inflammation and oxidative stress. However, its role in extracorporeal membrane oxygenation (ECMO), a life-saving intervention for severe cardiorespiratory failure associated with pronounced inflammation and oxidative stress, remains largely unexplored. This ex vivo study investigated whether ECMO could serve […]

BACKGROUND: Obesity increases the risk of developing chronic kidney disease and progression to kidney failure (KF) and precludes kidney transplantation (KT). Challenges exist in people with KF losing weight to access KT, therefore understanding patients' and clinicians lived experiences of obesity management is crucial to improving equitable access to KT. This review aimed to synthesise […]

The researchers who conduct, author and review neuroscience studies inherently shape both the findings and the segments of society that ultimately benefit from the research. Generally, Western high-income nations dominate the production and dissemination of the majority of prestigious scientific research. However, the extent of geographic disparities across the neuroscience research pipeline, including at the […]

BACKGROUND: Major injury contributes substantially to global morbidity and mortality, yet outcome measurement remains inconsistent. Development of a standardised set of patient-centred outcome measures for adults with major injuries has the potential to improve global benchmarking, quality of care and patient-centre value-based healthcare.

Transcatheter electrosurgery involves the precise application of high-frequency electrical currents to modify or perforate cardiac structures during structural heart interventions. Adoption of these techniques in the Asia-Pacific region has grown significantly alongside the expansion of structural heart programs. Techniques such as Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Coronary Artery Obstruction (BASILICA), Undermining […]

Increased survival of preterm infants born

CONCLUSION: This investigation reveals that although antibody specific for CPA is prevalent in pwCF, it cannot inhibit complement-killing of the majority of CPA expressing strains. Thus, when treating Pseudomonas by removing cloaking antibodies, it is unlikely that CPA-specific antibodies will also need to be eliminated.

PURPOSE: To address incomplete and inconsistent classification of pancreatic cancer resectability according to International Association of Pancreatology (IAP) anatomic, biologic, and conditional criteria.

BACKGROUND: Psychiatric disorders are common after traumatic brain injury, impeding recovery and increasing health and social costs internationally. clinicians caring for patients with TBI need an evidence base to support assessment of risk of and intervention to reduce psychiatric morbidity.

CONCLUSIONS: Lifestyle interventions in pregnancy are likely to prevent gestational diabetes, with effects varying according to diagnostic criteria. Implementation strategies should address inequalities by maternal education, and consider group formats, provider training, and physical activity based interventions to prevent gestational diabetes.

There is a well-documented relationship between the monoclonal antibody (MAB) denosumab and medication-related osteonecrosis of the jaw (MRONJ). However, the association between other MABs and MRONJ remains unclear. A systematic search was conducted across MEDLINE, Embase, and Web of Science to identify articles describing cases of MRONJ associated with the use of MABs excluding denosumab. […]

IntroductionEffective management of pulmonary exacerbations (PEx) in cystic fibrosis (CF) is essential to minimise lung damage and reduce morbidity and mortality. Spirometry, the standard tool for lung function assessment in adult people with CF (pwCF), has limitations. Forced Oscillometry Technique (FOT) is an effort-independent method that assesses small airways disease and has been validated in […]

OBJECTIVES: Cerebral microbleeds (CMBs), which present as foci of hypointensities on T2*-weighted Magnetic Resonance Imaging (MRI) are associated with weakened vessel walls. CMBs are also a frequent finding in traumatic brain injury (TBI) in association with poor outcome. We investigated whether a combination of susceptibility weighted imaging (SWI) and dynamic contrast enhanced (DCE) MRI could […]

CONCLUSIONS: Point of care testing could be a complimentary option to laboratory testing of lipoprotein(a), especially in remote areas. It may help (re-)stratify cardiovascular risk and help tailor treatment decisions.

CONCLUSIONS: This study finds a specific histologic appearance associated with untreated Q fever infection and poor outcomes in pregnancy. The histologic findings described should prompt reflex Q fever testing.